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Authordc.contributor.authorAcevedo, Cristián A. 
Authordc.contributor.authorQuiñones, Luis A. 
Authordc.contributor.authorCatalán, Johanna 
Authordc.contributor.authorCáceres, Dante D. 
Authordc.contributor.authorFullá, Juan A. 
Authordc.contributor.authorRoco, Angela M. 
Admission datedc.date.accessioned2019-03-15T16:06:08Z
Available datedc.date.available2019-03-15T16:06:08Z
Publication datedc.date.issued2014
Cita de ítemdc.identifier.citationUrologic Oncology: Seminars and Original Investigations, Volumen 32, Issue 3, 2018, Pages 280-290
Identifierdc.identifier.issn18732496
Identifierdc.identifier.issn10781439
Identifierdc.identifier.other10.1016/j.urolonc.2013.05.010
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/166126
Abstractdc.description.abstractObjective: Prognostic biomarkers that distinguish between patients with good or poor outcome can be used to guide decisions of whom to treat and how aggressively. In this sense, several groups have proposed genetic polymorphisms as potential susceptibility and prognostic biomarkers; however, their validity has not been proven. Thus, the main goal of the present work was to investigate the potential role of single and combined CYP1A1, GSTM1, and GSTT1 genotypes as modifiers of cancer survival in Chilean patients with prostate cancer. Methods and materials: A total of 260 histologically confirmed patients were recruited from a voluntary screening, and genomic DNA was obtained from their blood samples for genotyping analyses to detect the CYP1A1*2A polymorphism and GSTM1 and GSTT1 deletions. The progression of illness and mortality were estimated with a median follow-up of 8.82 years. Adjusted estimated genotype risks were evaluated by hazard ratio and 95% CI using the Cox proportional mo
Lenguagedc.language.isoen
Publisherdc.publisherElsevier Inc.
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceUrologic Oncology: Seminars and Original Investigations
Keywordsdc.subjectBiomarkers
Keywordsdc.subjectCYP
Keywordsdc.subjectGST
Keywordsdc.subjectPolymorphisms
Keywordsdc.subjectProstate cancer
Keywordsdc.subjectSurvival
Títulodc.titleImpact of CYP1A1, GSTM1, and GSTT1 polymorphisms in overall and specific prostate cancer survival
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile