Endothelial heterogeneity in the umbilico-placental unit: DNA methylation as an innuendo of epigenetic diversity
Author
dc.contributor.author
Casanello, Paola
Author
dc.contributor.author
Schneider, Daniela
Author
dc.contributor.author
Herrera, Emilio A.
Author
dc.contributor.author
Uauy Dagach-Imbarack, Ricardo
Author
dc.contributor.author
Krause, Bernardo J.
Admission date
dc.date.accessioned
2019-03-15T16:06:11Z
Available date
dc.date.available
2019-03-15T16:06:11Z
Publication date
dc.date.issued
2014
Cita de ítem
dc.identifier.citation
Frontiers in Pharmacology, Volumen 5 MAR,
Identifier
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16639812
Identifier
dc.identifier.other
10.3389/fphar.2014.00049
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/166139
Abstract
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The endothelium is a multifunctional heterogeneous tissue playing a key role in the physiology of every organ. To accomplish this role the endothelium presents a phenotypic diversity that is early prompted during vascular development, allowing it to cope with specific requirements in a time- and site-specific manner. During the last decade several reports show that endothelial diversity is also present in the umbilico-placental vasculature, with differences between macro- and microvascular vessels as well as arterial and venous endothelium. This diversity is evidenced in vitro as a higher angiogenic capacity in the microcirculation; or disparity in the levels of several molecules that control endothelial function (i.e., receptor for growth factors, vasoactive mediators, and adhesion molecules) which frequently are differentially expressed between arterial and venous endothelium. Emerging evidence suggests that endothelial diversity would be prominently driven by epigenetic mechanisms w