Changes in bone mineral density after sleeve Gastrectomy or gastric bypass: Relationships with variations in vitamin D, ghrelin, and adiponectin levels

Abstract

Background: A major long-term concern after gastric bypass (GBP) is the risk of osteoporosis; however, little is known about this complication in patients undergoing sleeve gastrectomy (SG). Objective: To evaluate changes in bone mineral density (BMD) after GBP and SG, and its relationship with changes in vitamin D, parathyroid hormone (PTH), ghrelin, and adiponectin. Methods: Twenty-three women undergoing GBP (BMI 42.0 ± 4.2 kg/m2; 37.3 ± 8.1 years) and 20 undergoing SG (BMI 37.3 ± 3.2 kg/m 2; 34.2 ± 10.2 years) were studied before and 6 and 12 months after surgery. BMD was measured by dual-energy X-ray absorptiometry. Plasma PTH, 25-hydroxyvitamin D (25-OHD), ghrelin, and adiponectin concentrations were determined. Food as well as calcium and vitamin D supplement intake was recorded. Results: Excess weight loss (mean ± SE), adjusted by baseline excess weight, was 79.1±3.8 % and 74.9 ± 4.1 % 1 year after GBP and SG, respectively (p = 0.481). Significant reduction in BMD for total body