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Authordc.contributor.authorTapia Opazo, Gladys 
Authordc.contributor.authorValenzuela, Rodrigo 
Authordc.contributor.authorEspinosa, Alejandra 
Authordc.contributor.authorRomanque, Pamela 
Authordc.contributor.authorDossi, Camila 
Authordc.contributor.authorGonzález Mañán, Daniel Alonso 
Authordc.contributor.authorVidela Cabrera, Luis 
Authordc.contributor.authorD'Espessailles Tapia, Amanda 
Cita de ítemdc.identifier.citationMolecular Nutrition and Food Research, Volumen 58, Issue 6, 2018, Pages 1333-1341
Abstractdc.description.abstractScope: Dietary n-3 long-chain PUFAs (n-3 LCPUFAs) supplementation was studied in an HFD-induced (HFD is high-fat diet) steatosis and inflammation in relation to peroxisome proliferator-activated receptor alpha (PPAR-α) and nuclear factor κB (NF-κB) signaling. Methods and results: Male C57BL/6J mice received (i) control diet (10% fat, 20% protein, 70% carbohydrate), (ii) control diet plus n-3 LCPUFAs (daily doses of 108 mg/kg body weight of eicosapentaenoic acid plus 92 mg/kg body weight of docosahexaenoic acid), (iii) HFD (60% fat, 20% protein, 20% carbohydrate), or (iv) HFD plus n-3 LCPUFAs for 12 wk. PPAR-α, tumor necrosis factor alpha (TNF-α), and IL-1β mRNA expression, acyl-CoA oxidase 1 (ACOX1), and carnitine-acyl-CoA transferase 1 (CAT-I) protein contents, and NF-κB DNA binding activity were measured. HFD significantly decreased liver PPAR-α, ACOX1, and CAT-I levels with NF-κB activation, higher TNF-α and IL-1β expression, and steatosis development. These changes were either redu
Publisherdc.publisherWiley-VCH Verlag
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceMolecular Nutrition and Food Research
Keywordsdc.subjectHigh-fat diet
Keywordsdc.subjectLiver steatosis
Keywordsdc.subjectn-3 long-chain PUFA
Keywordsdc.subjectNuclear factor κB
Keywordsdc.subjectPeroxisome proliferator-activated receptor alpha
Títulodc.titleN-3 long-chain PUFA supplementation prevents high fat diet induced mouse liver steatosis and inflammation in relation to PPAR-α upregulation and NF-κB DNA binding abrogation
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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