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Authordc.contributor.authorOcaranza, María Paz 
Authordc.contributor.authorMichea Acevedo, Luis 
Authordc.contributor.authorChiong Lay, Mario 
Authordc.contributor.authorLagos, Carlos F. 
Authordc.contributor.authorLavandero González, Sergio 
Authordc.contributor.authorJalil Milad, Jorge 
Admission datedc.date.accessioned2019-03-15T16:06:47Z
Available datedc.date.available2019-03-15T16:06:47Z
Publication datedc.date.issued2014
Cita de ítemdc.identifier.citationClinical Science, Volumen 127, Issue 9, 2018, Pages 549-557
Identifierdc.identifier.issn01435221
Identifierdc.identifier.other10.1042/CS20130449
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/166203
Abstractdc.description.abstractChronic RAS (renin-angiotensin system) activation by both AngII (angiotensin II) and aldosterone leads to hypertension and perpetuates a cascade of pro-hypertrophic, pro-inflammatory, pro-thrombotic and atherogenic effects associated with cardiovascular damage. In 2000, a new pathway consisting of ACE2 (angiotensin-converting enzyme2), Ang-(1-9) [angiotensin-(1-9)], Ang-(1-7) [angiotensin-(1-7)] and the Mas receptor was discovered. Activation of this novel pathway stimulates vasodilation, anti-hypertrophy and anti-hyperplasia. For some time, studies have focused mainly on ACE2, Ang-(1-7) and the Mas receptor, and their biological properties that counterbalance the ACE/AngII/AT1R (angiotensin type 1 receptor) axis. No previous information about Ang-(1-9) suggested that this peptide had biological properties. However, recent data suggest that Ang-(1-9) protects the heart and blood vessels (and possibly the kidney) from adverse cardiovascular remodelling in patients with hypertension and/
Lenguagedc.language.isoen
Publisherdc.publisherPortland Press Ltd
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceClinical Science
Keywordsdc.subjectAngiotensin II
Keywordsdc.subjectAngiotensin type 2 receptor (AT2R)
Keywordsdc.subjectAngiotensin-(1-9)
Keywordsdc.subjectCardiovascular damage
Keywordsdc.subjectRenin-angiotensin system
Títulodc.titleRecent insights and therapeutic perspectives of angiotensin-(1-9) in the cardiovascular system
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile