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Association of increased levels of TGF-β1 and p14ARF in prostate carcinoma cell lines overexpressing Egr-1
Autor | dc.contributor.author | Parra, Eduardo | |
Autor | dc.contributor.author | Gutiérrez, Luis | |
Autor | dc.contributor.author | Ferreira, Jorge | |
Fecha ingreso | dc.date.accessioned | 2019-03-15T16:07:36Z | |
Fecha disponible | dc.date.available | 2019-03-15T16:07:36Z | |
Fecha de publicación | dc.date.issued | 2014 | |
Cita de ítem | dc.identifier.citation | Oncology Reports, Volumen 32, Issue 5, 2018, Pages 2191-2198 | |
Identificador | dc.identifier.issn | 17912431 | |
Identificador | dc.identifier.issn | 1021335X | |
Identificador | dc.identifier.other | 10.3892/or.2014.3472 | |
Identificador | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/166250 | |
Resumen | dc.description.abstract | The present study examined the effect of the overexpression of early growth response gene (Egr-1) on transforming growth factor β-1 (TGF-β1) and p14ARFlevels, in PC-3 and LNCaP prostate carcinoma cell lines. Amplification of EGR-1, TGF-β1 and p14ARFwere observed in the two cell lines treated with different stimuli and resulted in a corresponding mRNA and protein expression. The downregulation of TGF-β1 and the attenuation of p14ARFexpression by siRNA against Egr-1 predominantly suggested that TGF-β1 and p14ARFmay be regulated by the transcription factor EGR-1. A marginal attenuation of cell growth in PC-3 and LNCaP prostate carcinoma cell lines overexpressing p14ARFwas observed. Cells transfected with Egr-1 wild-type were able to grow and avoid cell cycle arrest and apoptosis in the presence or absence of p14ARF. In addition, EGR-1 stimulated the expression of TGF β-l as well as the accumulation of the p14ARFproteins. The results suggested that TGF-β1 and p14ARFactivities in the presen | |
Idioma | dc.language.iso | en | |
Publicador | dc.publisher | Spandidos Publications | |
Tipo de licencia | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link a Licencia | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Fuente | dc.source | Oncology Reports | |
Palabras claves | dc.subject | EGR-1 | |
Palabras claves | dc.subject | P14ARF | |
Palabras claves | dc.subject | PC-3/LNCaP | |
Palabras claves | dc.subject | TGF-β1 | |
Título | dc.title | Association of increased levels of TGF-β1 and p14ARF in prostate carcinoma cell lines overexpressing Egr-1 | |
Tipo de documento | dc.type | Artículo de revista | |
dcterms.accessRights | dcterms.accessRights | Acceso Abierto | |
Catalogador | uchile.catalogador | SCOPUS | |
Indización | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI |
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