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Autordc.contributor.authorParra, Eduardo 
Autordc.contributor.authorGutiérrez, Luis 
Autordc.contributor.authorFerreira, Jorge 
Fecha ingresodc.date.accessioned2019-03-15T16:07:36Z
Fecha disponibledc.date.available2019-03-15T16:07:36Z
Fecha de publicacióndc.date.issued2014
Cita de ítemdc.identifier.citationOncology Reports, Volumen 32, Issue 5, 2018, Pages 2191-2198
Identificadordc.identifier.issn17912431
Identificadordc.identifier.issn1021335X
Identificadordc.identifier.other10.3892/or.2014.3472
Identificadordc.identifier.urihttps://repositorio.uchile.cl/handle/2250/166250
Resumendc.description.abstractThe present study examined the effect of the overexpression of early growth response gene (Egr-1) on transforming growth factor β-1 (TGF-β1) and p14ARFlevels, in PC-3 and LNCaP prostate carcinoma cell lines. Amplification of EGR-1, TGF-β1 and p14ARFwere observed in the two cell lines treated with different stimuli and resulted in a corresponding mRNA and protein expression. The downregulation of TGF-β1 and the attenuation of p14ARFexpression by siRNA against Egr-1 predominantly suggested that TGF-β1 and p14ARFmay be regulated by the transcription factor EGR-1. A marginal attenuation of cell growth in PC-3 and LNCaP prostate carcinoma cell lines overexpressing p14ARFwas observed. Cells transfected with Egr-1 wild-type were able to grow and avoid cell cycle arrest and apoptosis in the presence or absence of p14ARF. In addition, EGR-1 stimulated the expression of TGF β-l as well as the accumulation of the p14ARFproteins. The results suggested that TGF-β1 and p14ARFactivities in the presen
Idiomadc.language.isoen
Publicadordc.publisherSpandidos Publications
Tipo de licenciadc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link a Licenciadc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Fuentedc.sourceOncology Reports
Palabras clavesdc.subjectEGR-1
Palabras clavesdc.subjectP14ARF
Palabras clavesdc.subjectPC-3/LNCaP
Palabras clavesdc.subjectTGF-β1
Títulodc.titleAssociation of increased levels of TGF-β1 and p14ARF in prostate carcinoma cell lines overexpressing Egr-1
Tipo de documentodc.typeArtículo de revista
dcterms.accessRightsdcterms.accessRightsAcceso Abierto
Catalogadoruchile.catalogadorSCOPUS
Indizaciónuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Excepto si se señala otra cosa, la licencia del ítem se describe como Attribution-NonCommercial-NoDerivs 3.0 Chile