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Author dc.contributor.author Venkataswamy, Manjunatha M.
Author dc.contributor.author Ng, Tony W.
Author dc.contributor.author Kharkwal, Shalu S.
Author dc.contributor.author Carreño, Leandro J.
Author dc.contributor.author Johnson, Alison J.
Author dc.contributor.author Kunnath-Velayudhan, Shajo
Author dc.contributor.author Liu, Zheng
Author dc.contributor.author Bittman, Robert
Author dc.contributor.author Jervis, Peter J.
Author dc.contributor.author Cox, Liam R.
Author dc.contributor.author Besra, Gurdyal S.
Author dc.contributor.author Wen, Xiangshu
Author dc.contributor.author Yuan, Weiming
Author dc.contributor.author Tsuji, Moriya
Author dc.contributor.author Li, Xiangming
Author dc.contributor.author
Admission date dc.date.accessioned 2019-03-15T16:07:38Z
Available date dc.date.available 2019-03-15T16:07:38Z
Publication date dc.date.issued 2014
Cita de ítem dc.identifier.citation PLoS ONE, Volumen 9, Issue 9, 2018,
Identifier dc.identifier.issn 19326203
Identifier dc.identifier.other 10.1371/journal.pone.0108383
Identifier dc.identifier.uri https://repositorio.uchile.cl/handle/2250/166253
Abstract dc.description.abstract © 2014 Venkataswamy et al. Recombinant Mycobacterium bovis bacillus Calmette-Guèrin (rBCG) has been explored as a vector for vaccines against HIV because of its ability to induce long lasting humoral and cell mediated immune responses. To maximize the potential for rBCG vaccines to induce effective immunity against HIV, various strategies are being employed to improve its ability to prime CD8+T cells, which play an important role in the control of HIV infections. In this study we adopted a previously described approach of incorporating glycolipids that activate CD1d-restricted natural killer T (NKT) cells to enhance priming of CD8+T cells by rBCG strains expressing an SIV Gag antigen (rBCG-SIV gag). We found that the incorporation of the synthetic NKT activating glycolipid α-galactosylceramide (α-GC) into rBCG-SIV gag significantly enhanced CD8+T cell responses against an immunodominant Gag epitope, compared to responses primed by unmodified rBCG-SIV gag. The abilities of structural an
Lenguage dc.language.iso en
Publisher dc.publisher Public Library of Science
Type of license dc.rights Attribution-NonCommercial-NoDerivs 3.0 Chile
Link to License dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Source dc.source PLoS ONE
Keywords dc.subject Biochemistry, Genetics and Molecular Biology (all)
Keywords dc.subject Agricultural and Biological Sciences (all)
Título dc.title Improving Mycobacterium bovis bacillus calmette-Guèrin as a vaccine delivery vector for viral antigens by incorporation of glycolipid activators of NKT cells
Document type dc.type Artículo de revista
dcterms.accessRights dcterms.accessRights Acceso Abierto
Cataloguer uchile.catalogador SCOPUS
Indexation uchile.index Artículo de publicación SCOPUS
uchile.cosecha uchile.cosecha SI
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