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Author | dc.contributor.author | Bravo, David | |
Author | dc.contributor.author | Tello Ibarra, Paula | |
Author | dc.contributor.author | Retamal, Jeffri | |
Author | dc.contributor.author | Pelissier Serrano, Teresa | |
Author | dc.contributor.author | Laurido, Claudio | |
Author | dc.contributor.author | Hernández, Alejandro | |
Author | dc.contributor.author | Constandil, Luis | |
Admission date | dc.date.accessioned | 2019-03-15T16:07:41Z | |
Available date | dc.date.available | 2019-03-15T16:07:41Z | |
Publication date | dc.date.issued | 2014 | |
Cita de ítem | dc.identifier.citation | Pain, Volumen 155, Issue 10, 2018, Pages 2108-2115 | |
Identifier | dc.identifier.issn | 18726623 | |
Identifier | dc.identifier.issn | 03043959 | |
Identifier | dc.identifier.other | 10.1016/j.pain.2014.07.024 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/166269 | |
Abstract | dc.description.abstract | © 2014 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.Pannexin 1 (panx1) is a large-pore membrane channel expressed in many tissues of mammals, including neurons and glial cells. Panx1 channels are highly permeable to calcium and adenosine triphosphatase (ATP); on the other hand, they can be opened by ATP and glutamate, two crucial molecules for acute and chronic pain signaling in the spinal cord dorsal horn, thus suggesting that panx1 could be a key component for the generation of central sensitization during persistent pain. In this study, we examined the effect of three panx1 blockers, namely, 10panx peptide, carbenoxolone, and probenecid, on C-reflex wind-up activity and mechanical nociceptive behavior in a spared nerve injury neuropathic rat model involving sural nerve transection. In addition, the expression of panx1 protein in the dorsal horn of the ipsilateral lumbar spinal cord was measured in sural nerve-transected and sham-ope | |
Lenguage | dc.language.iso | en | |
Publisher | dc.publisher | Elsevier B.V. | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Pain | |
Keywords | dc.subject | 10panx | |
Keywords | dc.subject | C-reflex | |
Keywords | dc.subject | Carbenoxolone | |
Keywords | dc.subject | Central sensitization | |
Keywords | dc.subject | Neuropathic pain | |
Keywords | dc.subject | Pannexin 1 | |
Keywords | dc.subject | Paw pressure threshold | |
Keywords | dc.subject | Probenecid | |
Título | dc.title | Pannexin 1: A novel participant in neuropathic pain signaling in the rat spinal cord | |
Document type | dc.type | Artículo de revista | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile