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Author dc.contributor.author Guzmán, Mónica Andrews
Author dc.contributor.author Olguín, Miguel Arredondo
Admission date dc.date.accessioned 2019-03-15T16:07:44Z
Available date dc.date.available 2019-03-15T16:07:44Z
Publication date dc.date.issued 2014
Cita de ítem dc.identifier.citation Nutricion Hospitalaria, Volumen 30, Issue 3, 2018, Pages 577-584
Identifier dc.identifier.issn 16995198
Identifier dc.identifier.issn 02121611
Identifier dc.identifier.other 10.3305/nh.2014.30.3.7647
Identifier dc.identifier.uri https://repositorio.uchile.cl/handle/2250/166279
Abstract dc.description.abstract © 2014, Grupo Aula Medica S.A. All rights reserved.Obesity and Type 2 diabetes mellitus share a strong pro-inflammatory profile. It has been observed that iron is a risk factor in the development of type 2 diabetes. The aim of this study was to evaluate the relationship between iron nutritional status and inflammation with the risk of type 2 diabetes development in obese subjects. We studied 30 obese men with type 2 diabetes (OBDM); 30 obese subjects without diabetes (OB) and 30 healthy subjects (Cn). We isolated peripheral mononuclear cells (PMCs) and challenged them with high Fe concentrations. Total mRNA was isolated and relative abundance of TNF-α, IL-6 and hepcidin were determined by qPCR. Iron status, biochemical, inflammatory and oxidative stress parameters were also characterized. OBDM and OB patients showed increased hsCRP levels compared to the Cn group. OBDM subjects showed higher levels of ferritin than the Cn group. TNF-α and IL-6 mRNA relative abundances were increased in
Lenguage dc.language.iso en
Publisher dc.publisher Grupo Aula Medica S.A.
Type of license dc.rights Attribution-NonCommercial-NoDerivs 3.0 Chile
Link to License dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Source dc.source Nutricion Hospitalaria
Keywords dc.subject Ferritin
Keywords dc.subject Hepcidin
Keywords dc.subject Inflammatory cytokines
Keywords dc.subject Iron
Keywords dc.subject Obesity
Título dc.title Association between ferritin, high sensitivity c-reactive protein (hsCRP) and relative abundance of Hepcidin mRNA with the risk of type 2 diabetes in obese subjects RelaciÓn entre ferritina, pcrus y expresion de hepcidina con el riesgo de desarrollo de di
Document type dc.type Artículo de revista
Cataloguer uchile.catalogador SCOPUS
Indexation uchile.index Artículo de publicación SCOPUS
uchile.cosecha uchile.cosecha SI
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