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Author | dc.contributor.author | Tobar, Nicola´s | |
Author | dc.contributor.author | Toyos, Marcela | |
Author | dc.contributor.author | Urra, Carla | |
Author | dc.contributor.author | Me´ndez, Nicola´s | |
Author | dc.contributor.author | Arancibia, Rodrigo | |
Author | dc.contributor.author | Smith, Patricio C. | |
Author | dc.contributor.author | Marti´nez, Jorge | |
Admission date | dc.date.accessioned | 2019-03-15T16:07:49Z | |
Available date | dc.date.available | 2019-03-15T16:07:49Z | |
Publication date | dc.date.issued | 2014 | |
Cita de ítem | dc.identifier.citation | BMC Cancer, Volumen 14, Issue 1, 2018, | |
Identifier | dc.identifier.issn | 14712407 | |
Identifier | dc.identifier.other | 10.1186/1471-2407-14-640 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/166299 | |
Abstract | dc.description.abstract | © 2014 Tobar et al.; licensee BioMed Central Ltd. Background: Hard consistency, developed under the influence of tumor cell factors, is a characteristic feature of a breast tumor. Activation of resident fibroblasts leading to a myofibroblast phenotype is the principal feature that orchestrates this fibrotic process. The aim of this study was to assess the effects induced by TGF-β1, a growth factor abundantly present in tumor microenvironment, on the molecular mechanisms that mediate myofibroblastic differentiation of normal human mammary fibroblasts.Methods: We used an immortalized fibroblastic cell line derived from normal mammary tissue (RMF-EG cells) to study the effect of TGF-β1 in the expression of α-SMA and CTGF as markers of myofibroblastic differentiation. The influence of redox status and JNK activity on TGF-β1-induced transcriptional activity was measured by a luciferase reporter assay. We also used a shRNA approach to evaluate the influence of NOX4 in myofibroblastic differe | |
Lenguage | dc.language.iso | en | |
Publisher | dc.publisher | BioMed Central Ltd. | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | BMC Cancer | |
Keywords | dc.subject | Fibrosis | |
Keywords | dc.subject | JNK | |
Keywords | dc.subject | NOX-4 | |
Keywords | dc.subject | ROS | |
Título | dc.title | c-Jun N terminal kinase modulates NOX-4 derived ROS production and myofibroblasts differentiation in human breast stromal cells | |
Document type | dc.type | Artículo de revista | |
dcterms.accessRights | dcterms.accessRights | Acceso Abierto | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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