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Authordc.contributor.authorContreras Ferrat, Ariel Eduardo 
Authordc.contributor.authorLavandero González, Sergio 
Authordc.contributor.authorJaimovich Pérez, Enrique 
Authordc.contributor.authorKlip, Amira 
Admission datedc.date.accessioned2019-03-15T16:07:50Z
Available datedc.date.available2019-03-15T16:07:50Z
Publication datedc.date.issued2014
Cita de ítemdc.identifier.citationCell Calcium, Volumen 56, Issue 5, 2018, Pages 390-396
Identifierdc.identifier.issn15321991
Identifierdc.identifier.issn01434160
Identifierdc.identifier.other10.1016/j.ceca.2014.08.012
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/166305
Abstractdc.description.abstract© 2014 Elsevier Ltd. Striated muscles (skeletal and cardiac) are major physiological targets of insulin and this hormone triggers complex signaling pathways regulating cell growth and energy metabolism. Insulin increases glucose uptake into muscle cells by stimulating glucose transporter (GLUT4) translocation from intracellular compartments to the cell surface. The canonical insulin-triggered signaling cascade controlling this process is constituted by well-mapped tyrosine, lipid and serine/threonine phosphorylation reactions. In parallel to these signals, recent findings reveal insulin-dependent Ca2+ mobilization in skeletal muscle cells and cardiomyocytes. Specifically, insulin activates the sarco-endoplasmic reticulum (SER) channels that release Ca2+ into the cytosol i.e., the Ryanodine Receptor (RyR) and the inositol 1,4,5-triphosphate receptor (IP3R). In skeletal muscle cells, a rapid, insulin-triggered Ca2+ release occurs through RyR, that is brought about upon S-glutathionylatio
Lenguagedc.language.isoen
Publisherdc.publisherChurchill Livingstone
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceCell Calcium
Keywordsdc.subjectCa2+
Keywordsdc.subjectCardiomyocytes
Keywordsdc.subjectGLUT4
Keywordsdc.subjectInsulin
Keywordsdc.subjectIP3R
Keywordsdc.subjectMitochondria
Keywordsdc.subjectMyotubes
Keywordsdc.subjectNOX2
Keywordsdc.subjectRyR
Títulodc.titleCalcium signaling in insulin action on striated muscle
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile