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Author | dc.contributor.author | Raddatz, Natalia | |
Author | dc.contributor.author | Castillo, Juan P. | |
Author | dc.contributor.author | González, Carlos | |
Author | dc.contributor.author | Álvarez Araya, Osvaldo | |
Author | dc.contributor.author | Latorre, Ramón | |
Admission date | dc.date.accessioned | 2019-03-15T16:07:58Z | |
Available date | dc.date.available | 2019-03-15T16:07:58Z | |
Publication date | dc.date.issued | 2014 | |
Cita de ítem | dc.identifier.citation | Journal of Biological Chemistry, Volumen 289, Issue 51, 2018, Pages 35438-35454 | |
Identifier | dc.identifier.issn | 1083351X | |
Identifier | dc.identifier.issn | 00219258 | |
Identifier | dc.identifier.other | 10.1074/jbc.M114.612713 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/166337 | |
Abstract | dc.description.abstract | © 2014 by The American Society for Biochemistry and Molecular Biology, Inc. Expressed in somatosensory neurons of the dorsal root and trigeminal ganglion, the transient receptor potential melastatin 8 (TRPM8) channel is a Ca2+-permeable cation channel activated by cold, voltage, phosphatidylinositol 4,5-bisphosphate, and menthol. Although TRPM8 channel gating has been characterized at the single channel and macroscopic current levels, there is currently no consensus regarding the extent to which temperature and voltage sensors couple to the conduction gate. In this study, we extended the range of voltages where TRPM8-induced ionic currents were measured and made careful measurements of the maximum open probability the channel can attain at different temperatures by means of fluctuation analysis. The first direct measurements of TRPM8 channel temperature-driven conformational rearrangements provided here suggest that temperature alone is able to open the channel and that the opening rea | |
Lenguage | dc.language.iso | en | |
Publisher | dc.publisher | American Society for Biochemistry and Molecular Biology Inc. | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Journal of Biological Chemistry | |
Keywords | dc.subject | Biochemistry | |
Keywords | dc.subject | Molecular Biology | |
Keywords | dc.subject | Cell Biology | |
Título | dc.title | Temperature and voltage coupling to channel opening in transient receptor potential melastatin 8 (TRPM8) | |
Document type | dc.type | Artículo de revista | |
dcterms.accessRights | dcterms.accessRights | Acceso Abierto | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile