Factores de riesgo de ocurrencia y
gravedad de malformaciones congénitas
Author
dc.contributor.author
Canals Cifuentes, Andrea
Author
dc.contributor.author
Cavada Chacón, Gabriel
Author
dc.contributor.author
Nazer Herrera, Julio
Admission date
dc.date.accessioned
2019-03-15T16:08:56Z
Available date
dc.date.available
2019-03-15T16:08:56Z
Publication date
dc.date.issued
2014
Cita de ítem
dc.identifier.citation
Rev Med Chile 2014; 142: 1431-1439
Identifier
dc.identifier.issn
07176163
Identifier
dc.identifier.issn
00349887
Identifier
dc.identifier.other
10.4067/S0034-98872014001100010
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/166379
Abstract
dc.description.abstract
Background: The relative importance of congenital malformations as a cause
of death in the first year of life is increasing along with the control of preventable
causes of perinatal mortality. Aim: To identify risk factors for congenital malformations. Patients and Methods: Retrospective case-control study of births
registered in the database of The Latin American Collaborative Study of Congenital Malformations (ECLAMC), in the period 2001-2010. Results: Birth weight
and gestational age were significantly lower in cases than controls, behaving as
risk factors and associated with a greater severity of congenital malformations.
The risk and severity of congenital malformations increased along with mother’s
age. Fetal growth retardation, a history of congenital malformations in the
family, physical factors and acute illnesses of the mother in the first trimester of
pregnancy were also significant risk factors for congenital malformations and
their severity. The educational level of the mother was a protective factor for
congenital malformations and their severity. Conclusions: Variables previously
identified as risk factors for congenital malformations, were significantly related
with the occurrence of congenital malformations and their severity.