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Authordc.contributor.authorÁvalos, Yenniffer 
Authordc.contributor.authorCanales, Jimena 
Authordc.contributor.authorBravo Sagua, Roberto 
Authordc.contributor.authorCriollo Céspedes, Alfredo 
Authordc.contributor.authorLavandero González, Sergio 
Authordc.contributor.authorQuest, Andrew F. G. 
Admission datedc.date.accessioned2019-03-15T16:09:04Z
Available datedc.date.available2019-03-15T16:09:04Z
Publication datedc.date.issued2014
Cita de ítemdc.identifier.citationBioMed Research International, Volumen 2014,
Identifierdc.identifier.issn23146141
Identifierdc.identifier.issn23146133
Identifierdc.identifier.other10.1155/2014/603980
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/166410
Abstractdc.description.abstract© 2014 Yenniffer Ávalos et al. Autophagy is a highly regulated catabolic process that involves lysosomal degradation of proteins and organelles, mostly mitochondria, for the maintenance of cellular homeostasis and reduction of metabolic stress. Problems in the execution of this process are linked to different pathological conditions, such as neurodegeneration, aging, and cancer. Many of the proteins that regulate autophagy are either oncogenes or tumor suppressor proteins. Specifically, tumor suppressor genes that negatively regulate mTOR, such as PTEN, AMPK, LKB1, and TSC1/2 stimulate autophagy while, conversely, oncogenes that activate mTOR, such as class I PI3K, Ras, Rheb, and AKT, inhibit autophagy, suggesting that autophagy is a tumor suppressor mechanism. Consistent with this hypothesis, the inhibition of autophagy promotes oxidative stress, genomic instability, and tumorigenesis. Nevertheless, autophagy also functions as a cytoprotective mechanism under stress conditions, includ
Lenguagedc.language.isoen
Publisherdc.publisherHindawi Publishing Corporation
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceBioMed Research International
Keywordsdc.subjectBiochemistry, Genetics and Molecular Biology (all)
Keywordsdc.subjectImmunology and Microbiology (all)
Títulodc.titleTumor Suppression and Promotion by Autophagy
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile