Simvastatin exhibits antiproliferative effects on spheres derived from canine mammary carcinoma cells
Author
dc.contributor.author
Torres, Cristian G.
Author
dc.contributor.author
Olivares, Araceli
Author
dc.contributor.author
Stoore, Caroll
Admission date
dc.date.accessioned
2019-03-15T16:09:08Z
Available date
dc.date.available
2019-03-15T16:09:08Z
Publication date
dc.date.issued
2015
Cita de ítem
dc.identifier.citation
Oncology Reports 33: 2235-2244, 2015
Identifier
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17912431
Identifier
dc.identifier.issn
1021335X
Identifier
dc.identifier.other
10.3892/or.2015.3850
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/166427
Abstract
dc.description.abstract
Mammary cancer is the most frequent type of tumor in the female canine. Treatments are mainly limited to surgery and chemotherapy; however, these tumors may develop clinical recurrence, metastasis and chemoresistance. The existence of a subpopulation of cancer cells with stemness features called cancer stem-like cells, may explain in part these characteristics of tumor progression. The statins, potent blockers of cholesterol synthesis, have also shown antitumor effects on cancer mammary cells, changes mediated by a decrease in the isoprenylation of specific proteins. Few studies have shown that simvastatin, a lipophilic statin, sensitizes cancer stem-like cells eliminating drug resistance. The aim of the present study was to evaluate the effects of simvastatin on spheres derived from CF41-Mg canine mammary tumor cells, which were characterized by phenotypic and functional analyses. Spheres exhibited characteristics of stemness, primarily expressing a CD44+/CD24-/low phenotype, displayi