Impacto clínico de un sistema de
farmacovigilancia activa realizado
por un farmacéutico en el reporte y
subnotificación de reacciones adversas a
medicamentos
Author
dc.contributor.author
Sánchez, Ignacio
Author
dc.contributor.author
Amador, Cristián
Author
dc.contributor.author
Plaza, José Cristian
Author
dc.contributor.author
Correa, Gonzalo
Author
dc.contributor.author
Amador Carrasco, Roberto Antonio
Admission date
dc.date.accessioned
2019-03-15T16:09:10Z
Available date
dc.date.available
2019-03-15T16:09:10Z
Publication date
dc.date.issued
2014
Cita de ítem
dc.identifier.citation
Rev Med Chile 2014; 142: 998-1005
Identifier
dc.identifier.issn
07176163
Identifier
dc.identifier.issn
00349887
Identifier
dc.identifier.other
10.4067/S0034-98872014000800007
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/166435
Abstract
dc.description.abstract
Background: Despite the importance of notifying and preventing adverse
drug reactions (ADRs), they are under reported and their consequences are not
adequately evaluated. Aim: To assess the impact of a pharmacovigilance system
carried out by a pharmacist. Material and Methods: In an internal medicine
service, the spontaneous report of ADRs was compared blindly with an active
pharmacovigilance system in which a pharmacist detected, monitored and
prevented ADRs. Results: A total of 1,196 patients was included. Of these 604
were hospitalized in intervened wards, where 50 suspected ADRs in 47 patients
were reported. In non-intervened wards, only three ADRs were spontaneously
reported. Therefore, the pharmacovigilance system significantly improved the
detection and report of ADRs with a risk ratio of 15.4 (95% confidence intervals
4.8-49.1). Sixty six percent of ADRs were classified as severe. Antimicrobials
were the main group of medications causing ADRs in 44% of reports. Forty
three percent of ADRs were preventable and prolonged hospital stay by a mean
of eight days. Conclusions: An active pharmacovigilance system carried out
by pharmacists improves the detection of ADRs and promotes its prevention.
Impacto clínico de un sistema de
farmacovigilancia activa realizado
por un farmacéutico en el reporte y
subnotificación de reacciones adversas a
medicamentos
Title in another language
dc.title.alternative
Assessment of an active pharmacovigilance
system carried out by a pharmacist