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Authordc.contributor.authorParra, Víctor M. 
Authordc.contributor.authorMacho Fisher, Pilar 
Authordc.contributor.authorSánchez, Gina 
Authordc.contributor.authorDonoso Laurent, Paulina 
Authordc.contributor.authorDomenech Lira, Raúl 
Admission datedc.date.accessioned2019-03-18T11:52:24Z
Available datedc.date.available2019-03-18T11:52:24Z
Publication datedc.date.issued2015
Cita de ítemdc.identifier.citationJournal of Cardiovascular Pharmacology, Volumen 65, Issue 3, 2018, Pages 276-281
Identifierdc.identifier.issn15334023
Identifierdc.identifier.issn01602446
Identifierdc.identifier.other10.1097/FJC.0000000000000191
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/166507
Abstractdc.description.abstract© 2014 Wolters Kluwer Health, Inc. All rights reserved.We showed that exercise induces early and late myocardial preconditioning in dogs and that these effects are mediated through nicotinamide adenine dinucleotide phosphate reduced form (NADPH) oxidase activation. As the intracoronary administration of calcium induces preconditioning and exercise enhances the calcium inflow to the cell, we studied if this effect of exercise triggers exercise preconditioning independently of its hemodynamic effects. We analyzed in 81 dogs the effect of blocking sarcolemmal L-type Ca2+ channels with a low dose of verapamil on early and late preconditioning by exercise, and in other 50 dogs, we studied the effect of verapamil on NADPH oxidase activation in early exercise preconditioning. Exercise reduced myocardial infarct size by 76% and 52% (early and late windows respectively; P < 0.001 both), and these effects were abolished by a single low dose of verapamil given before exercise. This dose of verapa
Lenguagedc.language.isoen
Publisherdc.publisherLippincott Williams and Wilkins
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceJournal of Cardiovascular Pharmacology
Keywordsdc.subjectcalcium
Keywordsdc.subjectexercise
Keywordsdc.subjectmyocardial infarction
Keywordsdc.subjectpreconditioning
Títulodc.titleExercise preconditioning of myocardial infarct size in dogs is triggered by calcium
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile