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Authordc.contributor.authorCastillo, Juan P. 
Authordc.contributor.authorRui, Huan 
Authordc.contributor.authorBasilio, Daniel 
Authordc.contributor.authorDas, Avisek 
Authordc.contributor.authorRoux, Benoît 
Authordc.contributor.authorLatorre, Ramón 
Authordc.contributor.authorBezanilla, Francisco 
Authordc.contributor.authorHolmgren, Miguel 
Admission datedc.date.accessioned2019-03-18T11:53:08Z
Available datedc.date.available2019-03-18T11:53:08Z
Publication datedc.date.issued2015
Cita de ítemdc.identifier.citationNature Communications, Volumen 6,
Identifierdc.identifier.issn20411723
Identifierdc.identifier.other10.1038/ncomms8622
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/166605
Abstractdc.description.abstract© 2015 Macmillan Publishers Limited. All rights reserved. The Na<sup>+</sup>/K<sup>+</sup>-ATPase restores sodium (Na<sup>+</sup>) and potassium (K<sup>+</sup>) electrochemical gradients dissipated by action potentials and ion-coupled transport processes. As ions are transported, they become transiently trapped between intracellular and extracellular gates. Once the external gate opens, three Na<sup>+</sup> ions are released, followed by the binding and occlusion of two K<sup>+</sup> ions. While the mechanisms of Na<sup>+</sup> release have been well characterized by the study of transient Na<sup>+</sup> currents, smaller and faster transient currents mediated by external K<sup>+</sup> have been more difficult to study. Here we show that external K<sup>+</sup> ions travelling to their binding sites sense only a small fraction of the electric field as they rapidly and simultaneously become occluded. Consistent with these results, molecular dynamics simulations of a pump model show a wid
Lenguagedc.language.isoen
Publisherdc.publisherNature Publishing Group
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceNature Communications
Keywordsdc.subjectChemistry (all)
Keywordsdc.subjectBiochemistry, Genetics and Molecular Biology (all)
Keywordsdc.subjectPhysics and Astronomy (all)
Títulodc.titleMechanism of potassium ion uptake by the Na
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile