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Author | dc.contributor.author | Castillo, Juan P. | |
Author | dc.contributor.author | Rui, Huan | |
Author | dc.contributor.author | Basilio, Daniel | |
Author | dc.contributor.author | Das, Avisek | |
Author | dc.contributor.author | Roux, Benoît | |
Author | dc.contributor.author | Latorre, Ramón | |
Author | dc.contributor.author | Bezanilla, Francisco | |
Author | dc.contributor.author | Holmgren, Miguel | |
Admission date | dc.date.accessioned | 2019-03-18T11:53:08Z | |
Available date | dc.date.available | 2019-03-18T11:53:08Z | |
Publication date | dc.date.issued | 2015 | |
Cita de ítem | dc.identifier.citation | Nature Communications, Volumen 6, | |
Identifier | dc.identifier.issn | 20411723 | |
Identifier | dc.identifier.other | 10.1038/ncomms8622 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/166605 | |
Abstract | dc.description.abstract | © 2015 Macmillan Publishers Limited. All rights reserved. The Na<sup>+</sup>/K<sup>+</sup>-ATPase restores sodium (Na<sup>+</sup>) and potassium (K<sup>+</sup>) electrochemical gradients dissipated by action potentials and ion-coupled transport processes. As ions are transported, they become transiently trapped between intracellular and extracellular gates. Once the external gate opens, three Na<sup>+</sup> ions are released, followed by the binding and occlusion of two K<sup>+</sup> ions. While the mechanisms of Na<sup>+</sup> release have been well characterized by the study of transient Na<sup>+</sup> currents, smaller and faster transient currents mediated by external K<sup>+</sup> have been more difficult to study. Here we show that external K<sup>+</sup> ions travelling to their binding sites sense only a small fraction of the electric field as they rapidly and simultaneously become occluded. Consistent with these results, molecular dynamics simulations of a pump model show a wid | |
Lenguage | dc.language.iso | en | |
Publisher | dc.publisher | Nature Publishing Group | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Nature Communications | |
Keywords | dc.subject | Chemistry (all) | |
Keywords | dc.subject | Biochemistry, Genetics and Molecular Biology (all) | |
Keywords | dc.subject | Physics and Astronomy (all) | |
Título | dc.title | Mechanism of potassium ion uptake by the Na | |
Document type | dc.type | Artículo de revista | |
dcterms.accessRights | dcterms.accessRights | Acceso Abierto | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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