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Author dc.contributor.author Oliva, Carlos
Author dc.contributor.author Molina-Fernandez, Claudia
Author dc.contributor.author Maureira, Miguel
Author dc.contributor.author Candia, Noemi
Author dc.contributor.author López, Estefanía
Author dc.contributor.author Hassan, Bassem
Author dc.contributor.author Aerts, Stein
Author dc.contributor.author Cánovas, José
Author dc.contributor.author Olguín, Patricio
Author dc.contributor.author Sierralta, Jimena
Admission date dc.date.accessioned 2019-03-18T11:53:11Z
Available date dc.date.available 2019-03-18T11:53:11Z
Publication date dc.date.issued 2015
Cita de ítem dc.identifier.citation Developmental Neurobiology, Volumen 75, Issue 9, 2018, Pages 1018-1032
Identifier dc.identifier.issn 1932846X
Identifier dc.identifier.issn 19328451
Identifier dc.identifier.other 10.1002/dneu.22271
Identifier dc.identifier.uri https://repositorio.uchile.cl/handle/2250/166622
Abstract dc.description.abstract © 2015 Wiley Periodicals, Inc.During axon targeting, a stereotyped pattern of connectivity is achieved by the integration of intrinsic genetic programs and the response to extrinsic long and short-range directional cues. How this coordination occurs is the subject of intense study. Transcription factors play a central role due to their ability to regulate the expression of multiple genes required to sense and respond to these cues during development. Here we show that the transcription factor HNT regulates layer-specific photoreceptor axon targeting in Drosophila through transcriptional control of jbug/Filamin and multiple genes involved in axon guidance and cytoskeleton organization.Using a microarray analysis we identified 235 genes whose expression levels were changed by HNT overexpression in the eye primordia. We analyzed nine candidate genes involved in cytoskeleton regulation and axon guidance, six of which displayed significantly altered gene expression levels in hnt mutant reti
Lenguage dc.language.iso en
Publisher dc.publisher John Wiley and Sons Inc.
Type of license dc.rights Attribution-NonCommercial-NoDerivs 3.0 Chile
Link to License dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Source dc.source Developmental Neurobiology
Keywords dc.subject Axon targeting
Keywords dc.subject Drosophila
Keywords dc.subject Filamins
Keywords dc.subject Hindsight
Título dc.title Hindsight regulates photoreceptor axon targeting through transcriptional control of jitterbug/Filamin and multiple genes involved in axon guidance in Drosophila
Document type dc.type Artículo de revista
Cataloguer uchile.catalogador SCOPUS
Indexation uchile.index Artículo de publicación SCOPUS
uchile.cosecha uchile.cosecha SI
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