Chilean consensus of prevention, diagnosis and treatment of Clostridium difficile-associated diarrhea Consenso chileno de prevención, diagnóstico y tratamiento de la diarrea asociada a Clostridium difficile

Abstract

© 2016, Sociedad Chilena de Infectologia. All Rights Reserved. Background: Clostridium difficile-associated diarrhea (CDAD) has become very important due to the increase in its incidence, severity, recurrence and the associated economic burden. Having a national consensus guideline is essential to improve its management. Objective: To build a multidisciplinary and evidence-based consensus in prevention, diagnosis and treatment of CDAD. Methods: We convened a panel of experts in the field of infectious diseases, gastroenterology, evidence-based medicine and consensus methodology. The panel conducted a structured review of published literature in CDAD evaluating evidence levels and recommendation degree according to the methodology proposed by the GRADE working-group. A modified three-round Delphi technique was used to reach a consensus among the experts. Results: A group of 16 experts was established, 12 of them answered 18 clinically relevant questions. The levels of agreement achieved