Show simple item record
Author | dc.contributor.author | Maggi, Jaxaira | |
Author | dc.contributor.author | Schafer, Carolina | |
Author | dc.contributor.author | Ubilla Olguín, Gabriela | |
Author | dc.contributor.author | Catalán Martina, Diego | |
Author | dc.contributor.author | Schinnerling, Katina | |
Author | dc.contributor.author | Aguillón Gutiérrez, Juan Carlos | |
Admission date | dc.date.accessioned | 2019-03-18T11:53:39Z | |
Available date | dc.date.available | 2019-03-18T11:53:39Z | |
Publication date | dc.date.issued | 2015 | |
Cita de ítem | dc.identifier.citation | Frontiers in Immunology, Volumen 6, Issue SEP, 2018, | |
Identifier | dc.identifier.issn | 16643224 | |
Identifier | dc.identifier.other | 10.3389/fimmu.2015.00488 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/166689 | |
Abstract | dc.description.abstract | © 2015 Maggi, Schafer, Ubilla-Olguín, Catalán, Schinnerling and Aguillón. The interaction between dendritic cells (DCs) and T cells is crucial on immunity or tolerance induction. In an immature or semi-mature state, DCs induce tolerance through T-cell deletion, generation of regulatory T cells, and/or induction of T-cell anergy. Anergy is defined as an unresponsive state that retains T cells in an "off" mode under conditions in which immune activation is undesirable. This mechanism is crucial for the control of T-cell responses against self-antigens, thereby preventing autoimmunity. Tolerogenic DCs (tDCs), generated in vitro from peripheral blood monocytes of healthy donors or patients with autoimmune pathologies, were shown to modulate immune responses by inducing T-cell hyporesponsiveness. Animal models of autoimmune diseases confirmed the impact of T-cell anergy on disease development and progression in vivo. Thus, the induction of T-cell hyporesponsiveness by tDCs has become a prom | |
Lenguage | dc.language.iso | en | |
Publisher | dc.publisher | Frontiers Media S.A. | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Frontiers in Immunology | |
Keywords | dc.subject | Autoimmune diseases | |
Keywords | dc.subject | Hyporesponsiveness | |
Keywords | dc.subject | Immunotherapy | |
Keywords | dc.subject | Regulatory T cells | |
Keywords | dc.subject | T-cell anergy | |
Keywords | dc.subject | Tolerogenic dendritic cells | |
Título | dc.title | Therapeutic potential of hyporesponsive CD4+ T cells in autoimmunity | |
Document type | dc.type | Artículo de revista | |
dcterms.accessRights | dcterms.accessRights | Acceso Abierto | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
Files in this item
- Name:
- pdf
- Size:
- 142.1Kb
- Format:
- PDF
This item appears in the following Collection(s)
Show simple item record
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile