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Authordc.contributor.authorBrys, Ivani 
Authordc.contributor.authorBobela, Wojciech 
Authordc.contributor.authorSchneider, Bernard L. 
Authordc.contributor.authorAebischer, Patrick 
Authordc.contributor.authorFuentes, Romulo 
Admission datedc.date.accessioned2019-03-18T11:53:46Z
Available datedc.date.available2019-03-18T11:53:46Z
Publication datedc.date.issued2017
Cita de ítemdc.identifier.citationInternational Journal of Neuroscience, Volumen 127, Issue 1, 2018, Pages 28-36
Identifierdc.identifier.issn15635279
Identifierdc.identifier.issn00207454
Identifierdc.identifier.other10.3109/00207454.2016.1138296
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/166725
Abstractdc.description.abstractCopyright © 2016 Informa UK Limited, trading as Taylor & Francis Group.Neuromodulation by spinal cord stimulation has been proposed as a symptomatic treatment for Parkinson’s disease. We tested the chronic effects of spinal cord stimulation in a progressive model of Parkinson’s based on overexpression of alpha-synuclein in the substantia nigra. Adult Sprague Dawley rats received unilateral injections of adeno-associated virus serotype 6 (AAV6) in the substantia nigra to express alpha-synuclein. Locomotion and forepaw use of the rats were evaluated during the next 10 weeks. Starting on week 6, a group of AAV6-injected rats received spinal cord stimulation once a week. At the end of the experiment, tyrosine hydroxylase and alpha-synuclein immunostaining were performed. Rats with unilateral alpha-synuclein expression showed a significant decrease in the use of the contralateral forepaw, which was mildly but significantly reverted by spinal cord stimulation applied once a week from the 6th
Lenguagedc.language.isoen
Publisherdc.publisherTaylor and Francis Ltd
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceInternational Journal of Neuroscience
Keywordsdc.subjectalpha-synuclein
Keywordsdc.subjectParkinson’s disease
Keywordsdc.subjectspinal cord stimulation
Títulodc.titleSpinal cord stimulation improves forelimb use in an alpha-synuclein animal model of Parkinson’s disease
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile