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Author | dc.contributor.author | Brys, Ivani | |
Author | dc.contributor.author | Bobela, Wojciech | |
Author | dc.contributor.author | Schneider, Bernard L. | |
Author | dc.contributor.author | Aebischer, Patrick | |
Author | dc.contributor.author | Fuentes, Romulo | |
Admission date | dc.date.accessioned | 2019-03-18T11:53:46Z | |
Available date | dc.date.available | 2019-03-18T11:53:46Z | |
Publication date | dc.date.issued | 2017 | |
Cita de ítem | dc.identifier.citation | International Journal of Neuroscience, Volumen 127, Issue 1, 2018, Pages 28-36 | |
Identifier | dc.identifier.issn | 15635279 | |
Identifier | dc.identifier.issn | 00207454 | |
Identifier | dc.identifier.other | 10.3109/00207454.2016.1138296 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/166725 | |
Abstract | dc.description.abstract | Copyright © 2016 Informa UK Limited, trading as Taylor & Francis Group.Neuromodulation by spinal cord stimulation has been proposed as a symptomatic treatment for Parkinson’s disease. We tested the chronic effects of spinal cord stimulation in a progressive model of Parkinson’s based on overexpression of alpha-synuclein in the substantia nigra. Adult Sprague Dawley rats received unilateral injections of adeno-associated virus serotype 6 (AAV6) in the substantia nigra to express alpha-synuclein. Locomotion and forepaw use of the rats were evaluated during the next 10 weeks. Starting on week 6, a group of AAV6-injected rats received spinal cord stimulation once a week. At the end of the experiment, tyrosine hydroxylase and alpha-synuclein immunostaining were performed. Rats with unilateral alpha-synuclein expression showed a significant decrease in the use of the contralateral forepaw, which was mildly but significantly reverted by spinal cord stimulation applied once a week from the 6th | |
Lenguage | dc.language.iso | en | |
Publisher | dc.publisher | Taylor and Francis Ltd | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | International Journal of Neuroscience | |
Keywords | dc.subject | alpha-synuclein | |
Keywords | dc.subject | Parkinson’s disease | |
Keywords | dc.subject | spinal cord stimulation | |
Título | dc.title | Spinal cord stimulation improves forelimb use in an alpha-synuclein animal model of Parkinson’s disease | |
Document type | dc.type | Artículo de revista | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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