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Author | dc.contributor.author | Salas, Daniela | |
Author | dc.contributor.author | Puebla, Carlos | |
Author | dc.contributor.author | Lampe, Paul D. | |
Author | dc.contributor.author | Lavandero González, Sergio | |
Author | dc.contributor.author | Sáez, Juan Carlos | |
Admission date | dc.date.accessioned | 2019-03-18T11:53:46Z | |
Available date | dc.date.available | 2019-03-18T11:53:46Z | |
Publication date | dc.date.issued | 2015 | |
Cita de ítem | dc.identifier.citation | Biochimica et Biophysica Acta - Molecular Basis of Disease, Volumen 1852, Issue 7, 2018, Pages 1268-1277 | |
Identifier | dc.identifier.issn | 1879260X | |
Identifier | dc.identifier.issn | 09254439 | |
Identifier | dc.identifier.other | 10.1016/j.bbadis.2015.03.004 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/166727 | |
Abstract | dc.description.abstract | © 2015 Elsevier B.V. Connexin hemichannels are regulated under physiological and pathological conditions. Metabolic inhibition, a model of ischemia, promotes surface hemichannel activation associated, in part, with increased surface hemichannel levels, but little is known about its underlying mechanism. Here, we investigated the role of Akt on the connexin43 hemichannel's response induced by metabolic inhibition. In HeLa cells stably transfected with rat connexin43 fused to EGFP (HeLa43 cells), metabolic inhibition induced a transient Akt activation necessary to increase the amount of surface connexin43. The increase in levels of surface connexin43 was also found to depend on an intracellular Ca2+ signal increase that was partially mediated by Akt activation. However, the metabolic inhibition-induced Akt activation was not significantly affected by intracellular Ca2+ chelation. The Akt-dependent increase in connexin43 hemichannel activity in HeLa43 cells also occurred after oxygen-gluc | |
Lenguage | dc.language.iso | en | |
Publisher | dc.publisher | Elsevier | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Biochimica et Biophysica Acta - Molecular Basis of Disease | |
Keywords | dc.subject | Akt activation | |
Keywords | dc.subject | Intracellular Ca2+ | |
Keywords | dc.subject | Oxygen-glucose deprivation | |
Keywords | dc.subject | Surface hemichannels | |
Título | dc.title | Role of Akt and Ca2+ on cell permeabilization via connexin43 hemichannels induced by metabolic inhibition | |
Document type | dc.type | Artículo de revista | |
dcterms.accessRights | dcterms.accessRights | Acceso Abierto | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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