Epigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary Syndrome
Author | dc.contributor.author | Kokosar, Milana | |
Author | dc.contributor.author | Benrick, Anna | |
Author | dc.contributor.author | Perfilyev, Alexander | |
Author | dc.contributor.author | Fornes, Romina | |
Author | dc.contributor.author | Nilsson, Emma | |
Author | dc.contributor.author | Maliqueo Yevilao, Manuel | |
Author | dc.contributor.author | Behre, Carl Johan | |
Author | dc.contributor.author | Sazonova, Antonina | |
Author | dc.contributor.author | Ohlsson, Claes | |
Author | dc.contributor.author | Ling, Charlotte | |
Author | dc.contributor.author | Stener-Victorin, Elisabet | |
Admission date | dc.date.accessioned | 2019-03-18T11:54:13Z | |
Available date | dc.date.available | 2019-03-18T11:54:13Z | |
Publication date | dc.date.issued | 2016 | |
Cita de ítem | dc.identifier.citation | Scientific Reports, Volumen 6, | |
Identifier | dc.identifier.issn | 20452322 | |
Identifier | dc.identifier.other | 10.1038/srep22883 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/166761 | |
Abstract | dc.description.abstract | Genetic and epigenetic factors may predispose women to polycystic ovary syndrome (PCOS), a common heritable disorder of unclear etiology. Here we investigated differences in genome-wide gene expression and DNA methylation in adipose tissue from 64 women with PCOS and 30 controls. In total, 1720 unique genes were differentially expressed (Q < 0.05). Six out of twenty selected genes with largest expression difference (CYP1B1, GPT), genes linked to PCOS (RAB5B) or type 2 diabetes (PPARG, SVEP1), and methylation (DMAP1) were replicated in a separate case-control study. In total, 63,213 sites (P < 0.05) and 440 sites (Q < 0.15) were differently methylated. Thirty differentially expressed genes had corresponding changes in 33 different DNA methylation sites. Moreover, a total number of 1913 pairs of differentially expressed 'gene-CpG' probes were significantly correlated after correction for multiple testing and corresponded with 349 unique genes. In conclusion, we identified a large number | |
Lenguage | dc.language.iso | en | |
Publisher | dc.publisher | Nature Publishing Group | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Scientific Reports | |
Keywords | dc.subject | Multidisciplinary | |
Título | dc.title | Epigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary Syndrome | |
Document type | dc.type | Artículo de revista | |
dcterms.accessRights | dcterms.accessRights | Acceso Abierto | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI |
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