Show simple item record

Authordc.contributor.authorValenzuela, Vicente 
Authordc.contributor.authorMartínez, Gabriela 
Authordc.contributor.authorDurán Aniotz, Claudia 
Authordc.contributor.authorHetz Flores, Claudio
Cita de ítemdc.identifier.citationBrain Research, Volumen 1648,
Abstractdc.description.abstract© 2016 Elsevier B.V. Gene therapy based on the use of Adeno-associated viruses (AAVs) is emerging as a safe and stable strategy to target molecular pathways involved in a variety of brain diseases. Endoplasmic reticulum (ER) stress is proposed as a transversal feature of most animal models and clinical samples from patients affected with neurodegenerative diseases. Manipulation of the unfolded protein response (UPR), a major homeostatic reaction under ER stress conditions, had proved beneficial in diverse models of neurodegeneration. Although increasing number of drugs are available to target ER stress, the use of small molecules to treat chronic brain diseases is challenging because of poor blood brain barrier permeability and undesirable side effects due to the role of the UPR in the physiology of peripheral organs. Gene therapy is currently considered a possible future alternative to circumvent these problems by the delivery of therapeutic agents to selective regions and cell types
Publisherdc.publisherElsevier B.V.
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceBrain Research
Keywordsdc.subjectAlzheimer's disease
Keywordsdc.subjectAmyotrophic lateral sclerosis
Keywordsdc.subjectEndoplasmic reticulum stress
Keywordsdc.subjectGene therapy
Keywordsdc.subjectParkinson's disease
Keywordsdc.subjectUnfolded protein response
Títulodc.titleGene therapy to target ER stress in brain diseases
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile