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Autordc.contributor.authorAlvarez, Carolina 
Autordc.contributor.authorAravena, Andrés 
Autordc.contributor.authorTapia, Teresa 
Autordc.contributor.authorRozenblum, Ester 
Autordc.contributor.authorSolís, Luisa 
Autordc.contributor.authorCorvalán, Alejandro 
Autordc.contributor.authorCamus, Mauricio 
Autordc.contributor.authorAcevedo Alvarez, Manuel 
Autordc.contributor.authorMunroe, David 
Autordc.contributor.authorMaass Sepúlveda, Alejandro 
Autordc.contributor.authorCarvallo, Pilar 
Fecha ingresodc.date.accessioned2019-03-18T11:54:18Z
Fecha disponibledc.date.available2019-03-18T11:54:18Z
Fecha de publicacióndc.date.issued2016
Cita de ítemdc.identifier.citationBMC Cancer, Volumen 16, Issue 1, 2018,
Identificadordc.identifier.issn14712407
Identificadordc.identifier.other10.1186/s12885-016-2261-x
Identificadordc.identifier.urihttps://repositorio.uchile.cl/handle/2250/166793
Resumendc.description.abstract© 2016 Alvarez et al.Background: Array CGH analysis of breast tumors has contributed to the identification of different genomic profiles in these tumors. Loss of DNA repair by BRCA1 functional deficiency in breast cancer has been proposed as a relevant contribution to breast cancer progression for tumors with no germline mutation. Identifying the genomic alterations taking place in BRCA1 not expressing tumors will lead us to a better understanding of the cellular functions affected in this heterogeneous disease. Moreover, specific genomic alterations may contribute to the identification of potential therapeutic targets and offer a more personalized treatment to breast cancer patients. Methods: Forty seven tumors from hereditary breast cancer cases, previously analyzed for BRCA1 expression, and screened for germline BRCA1 and 2 mutations, were analyzed by Array based Comparative Genomic Hybridization (aCGH) using Agilent 4x44K arrays. Overall survival was established for tumors in diffe
Idiomadc.language.isoen
Publicadordc.publisherBioMed Central Ltd.
Tipo de licenciadc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link a Licenciadc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Fuentedc.sourceBMC Cancer
Palabras clavesdc.subjectArray CGH
Palabras clavesdc.subjectBRCAX
Palabras clavesdc.subjectBreast cancer
Palabras clavesdc.subjectGenomic gains
Palabras clavesdc.subjectGenomic losses
Palabras clavesdc.subjectOncogenes
Palabras clavesdc.subjectTumor suppressor
Títulodc.titleDifferent Array CGH profiles within hereditary breast cancer tumors associated to BRCA1 expression and overall survival
Tipo de documentodc.typeArtículo de revista
dcterms.accessRightsdcterms.accessRightsAcceso Abierto
Catalogadoruchile.catalogadorSCOPUS
Indizaciónuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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