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Author | dc.contributor.author | Pouché, Lucie | |
Author | dc.contributor.author | Koitka, Matthias | |
Author | dc.contributor.author | Stojanova, Jana | |
Author | dc.contributor.author | Woillard, Jean Baptiste | |
Author | dc.contributor.author | Monchaud, Caroline | |
Author | dc.contributor.author | Villeneuve, Claire | |
Author | dc.contributor.author | Essig, Marie | |
Author | dc.contributor.author | Abraham, Julie | |
Author | dc.contributor.author | Le Meur, Yannick | |
Author | dc.contributor.author | Rerolle, Jean Phillippe | |
Author | dc.contributor.author | Kamar, Nassim | |
Author | dc.contributor.author | Rostaing, Lionel | |
Author | dc.contributor.author | Merville, Pierre | |
Author | dc.contributor.author | Gandia, Peggy | |
Author | dc.contributor.author | Bouchet, Stepha | |
Admission date | dc.date.accessioned | 2019-03-18T11:54:21Z | |
Available date | dc.date.available | 2019-03-18T11:54:21Z | |
Publication date | dc.date.issued | 2016 | |
Cita de ítem | dc.identifier.citation | Pharmacogenomics, Volumen 17, Issue 4, 2018, Pages 375-391 | |
Identifier | dc.identifier.issn | 17448042 | |
Identifier | dc.identifier.issn | 14622416 | |
Identifier | dc.identifier.other | 10.2217/pgs.15.181 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/166804 | |
Abstract | dc.description.abstract | © 2016 Future Medicine Ltd.Aim: To investigate the potential influence of variants in genes involved in the calcineurin pathway on the efficacy and toxicity of calcineurin inhibitors in renal transplantation. Materials & methods: Twenty-three polymorphisms in thirteen genes were tested in 381 renal transplant recipients receiving ciclosporin (n = 221) or tacrolimus (n = 160) and mycophenolate mofetil. Data were collected prospectively over the first year post-transplantation. Results: Multivariate survival analyses revealed no genetic associations with biopsy proven acute graft rejection and serious infections. Donor-recipient Cytomegalovirus mismatch was the only variable associated with serious infection. Conclusion: This large exploratory study casts doubts on the potential interest of genetic biomarkers related to CNI pharmacodynamics but associations with other phenotypes in transplantation deserve further studies. | |
Lenguage | dc.language.iso | en | |
Publisher | dc.publisher | Future Medicine Ltd. | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Pharmacogenomics | |
Keywords | dc.subject | acute rejection | |
Keywords | dc.subject | calcineurin | |
Keywords | dc.subject | ciclosporin | |
Keywords | dc.subject | genetic polymorphism | |
Keywords | dc.subject | kidney transplantation | |
Keywords | dc.subject | opportunistic infections | |
Keywords | dc.subject | pharmacogenetics | |
Keywords | dc.subject | tacrolimus | |
Título | dc.title | A candidate gene approach of the calcineurin pathway to identify variants associated with clinical outcomes in renal transplantation | |
Document type | dc.type | Artículo de revista | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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