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Authordc.contributor.authorSilva Marambio, Felipe 
Authordc.contributor.authorNavea, Daniel 
Authordc.contributor.authorSalas, Carolina 
Authordc.contributor.authorTorres, Juan P. 
Authordc.contributor.authorCatalán, Paula 
Authordc.contributor.authorMorales, Jorge 
Admission datedc.date.accessioned2019-03-18T11:54:21Z
Available datedc.date.available2019-03-18T11:54:21Z
Publication datedc.date.issued2016
Cita de ítemdc.identifier.citationRevista Chilena de Infectologia, Volumen 33, Issue 2, 2018, Pages 127-134
Identifierdc.identifier.issn07161018
Identifierdc.identifier.other10.4067/S0716-10182016000200001
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/166808
Abstractdc.description.abstract© 2016, Sociedad Chilena de Infectologia. All rights reserved.Background: Voriconazole (VCZ) serum drug levels (SDL) vary widely and are associated with increased mortality when they are below the therapeutic range for invasive aspergillosis (IA). Aim: To describe VCZ SDL in oncology pediatric patients in order to reach adequate concentrations for prophylaxis (≥ 0.5 mg/L) and treatment (≥ 1.0 y 2.0 mg/L) for IA and their relationship with toxicity. Patients and Methods: Retrospective analysis of VCZ SDL and toxicities recorded in oncology pediatric patients between February 2013 and November 2014. The daily dosage and SDLs were analyzed according to administration route: intravenous (IV) and oral (PO), type of therapy (prophylaxis and treatment) and patient age (< 12 y ≥ 12 years old). Results: 112 through levels from 26 patients were analyzed and the average age was 9.3 years-old. The SDL obtained from the IV route were 43.7%. There were more SDL ≥ 0.5 mg/L and ≥ 1.0 mg/L with the IV
Lenguagedc.language.isoen
Publisherdc.publisherSociedad Chilena de Infectologia
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceRevista Chilena de Infectologia
Keywordsdc.subjectAdverse drug reactions
Keywordsdc.subjectPharmacokinetics
Keywordsdc.subjectSerum concentration
Keywordsdc.subjectVoriconazole
Títulodc.titleAnalysis of voriconazole serum concentrations and safety profile in pediatric oncology patients Análisis de concentraciones plasmáticas de voriconazol y su perfil de seguridad en pacientes oncológicos pediátricos
Document typedc.typeArtículo de revista
dcterms.accessRightsdcterms.accessRightsAcceso Abierto
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile