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Author | dc.contributor.author | Maldonado, H. | |
Author | dc.contributor.author | Calderon, C. | |
Author | dc.contributor.author | Burgos Bravo, Francesca | |
Author | dc.contributor.author | Kobler, Oliver | |
Author | dc.contributor.author | Zuschratter, W. | |
Author | dc.contributor.author | Ramirez, O. | |
Author | dc.contributor.author | Härtel, S. | |
Author | dc.contributor.author | Schneider, P. | |
Author | dc.contributor.author | Quest, Andrew F. G. | |
Author | dc.contributor.author | Herrera-Molina, R. | |
Author | dc.contributor.author | Leyton, L. | |
Admission date | dc.date.accessioned | 2019-03-18T11:55:03Z | |
Available date | dc.date.available | 2019-03-18T11:55:03Z | |
Publication date | dc.date.issued | 2017 | |
Cita de ítem | dc.identifier.citation | Biochimica et Biophysica Acta - Molecular Cell Research, Volumen 1864, Issue 2, 2018, Pages 243-254 | |
Identifier | dc.identifier.issn | 18792596 | |
Identifier | dc.identifier.issn | 01674889 | |
Identifier | dc.identifier.other | 10.1016/j.bbamcr.2016.11.006 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/166920 | |
Abstract | dc.description.abstract | © 2016 Elsevier B.V. Two key proteins for cellular communication between astrocytes and neurons are αvβ3 integrin and the receptor Thy-1. Binding of these molecules in the same (cis) or on adjacent (trans) cellular membranes induces Thy-1 clustering, triggering actin cytoskeleton remodeling. Molecular events that could explain how the Thy-1-αvβ3 integrin interaction signals have only been studied separately in different cell types, and the detailed transcellular communication and signal transduction pathways involved in neuronal cytoskeleton remodeling remain unresolved. Using biochemical and genetic approaches, single-molecule tracking, and high-resolution nanoscopy, we provide evidence that upon binding to αvβ3 integrin, Thy-1 mobility decreased while Thy-1 nanocluster size increased. This occurred concomitantly with inactivation and exclusion of the non-receptor tyrosine kinase Src from the Thy-1/C-terminal Src kinase (Csk)-binding protein (CBP)/Csk complex. The Src inactivation dec | |
Lenguage | dc.language.iso | en | |
Publisher | dc.publisher | Elsevier B.V. | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Biochimica et Biophysica Acta - Molecular Cell Research | |
Keywords | dc.subject | Cell adhesion molecules | |
Keywords | dc.subject | GPI-anchored proteins | |
Keywords | dc.subject | Interaction in trans | |
Keywords | dc.subject | RhoA | |
Keywords | dc.subject | STED microscopy | |
Keywords | dc.subject | αvβ3 integrin | |
Título | dc.title | Astrocyte-to-neuron communication through integrin-engaged Thy-1/CBP/Csk/Src complex triggers neurite retraction via the RhoA/ROCK pathway | |
Document type | dc.type | Artículo de revista | |
dcterms.accessRights | dcterms.accessRights | Acceso Abierto | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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