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Authordc.contributor.authorPiquer, Beatriz 
Authordc.contributor.authorFonseca, Jose L. 
Authordc.contributor.authorLara Peñaloza, Hernán 
Admission datedc.date.accessioned2019-03-18T11:55:27Z
Available datedc.date.available2019-03-18T11:55:27Z
Publication datedc.date.issued2017
Cita de ítemdc.identifier.citationReproduction, Volumen 153, Issue 2, 2018, Pages 147-155
Identifierdc.identifier.issn17417899
Identifierdc.identifier.issn14701626
Identifierdc.identifier.other10.1530/REP-16-0312
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/166957
Abstractdc.description.abstract© 2017 Society for Reproduction and Fertility.Chronic cold stress produces adrenergic overload that can affect fetal development. The placental norepinephrine transporter (NET) clears norepinephrine (NE) from both maternal circulation and the fetus during gestation. If this system fails, NE clearance can be reduced, leading to high fetal exposure to NE. The main aim of this study was to determine the changes in NET expression during gestation and their relationship with the functional capacity of NET to transport NE under stressful conditions. Additionally, this study correlated these findings with the reproductive capacity of 2nd-generation progeny. Pregnant rats were subjected to chronic cold stress at 4°C for 3 h each day throughout their pregnancies. We found that exposure of pregnant rats to sympathetic stress caused the following effects: increased NE and corticosterone levels throughout pregnancy, decreased capacity of the placenta to clear NE from the fetus to the mother's circ
Lenguagedc.language.isoen
Publisherdc.publisherBioScientifica Ltd.
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceReproduction
Keywordsdc.subjectReproductive Medicine
Keywordsdc.subjectEmbryology
Keywordsdc.subjectEndocrinology
Keywordsdc.subjectObstetrics and Gynecology
Keywordsdc.subjectCell Biology
Títulodc.titleGestational stress, placental norepinephrine transporter and offspring fertility
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile