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Author | dc.contributor.author | Parra, Valentina | |
Author | dc.contributor.author | Rothermel, Beverly A. | |
Admission date | dc.date.accessioned | 2019-03-18T11:55:32Z | |
Available date | dc.date.available | 2019-03-18T11:55:32Z | |
Publication date | dc.date.issued | 2017 | |
Cita de ítem | dc.identifier.citation | Journal of Molecular and Cellular Cardiology, Volumen 103, | |
Identifier | dc.identifier.issn | 10958584 | |
Identifier | dc.identifier.issn | 00222828 | |
Identifier | dc.identifier.other | 10.1016/j.yjmcc.2016.12.006 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/166981 | |
Abstract | dc.description.abstract | © 2016 Elsevier LtdThe calcium-activated protein phosphatase, calcineurin, lies at the intersection of protein phosphorylation and calcium signaling cascades, where it provides an essential nodal point for coordination between these two fundamental modes of intracellular communication. In excitatory cells, such as neurons and cardiomyocytes, that experience rapid and frequent changes in cytoplasmic calcium, calcineurin protein levels are exceptionally high, suggesting that these cells require high levels of calcineurin activity. Yet, it is widely recognized that excessive activation of calcineurin in the heart contributes to pathological hypertrophic remodeling and the progression to failure. How does a calcium activated enzyme function in the calcium-rich environment of the continuously contracting heart without pathological consequences? This review will discuss the wide range of calcineurin substrates relevant to cardiovascular health and the mechanisms calcineurin uses to find and | |
Lenguage | dc.language.iso | en | |
Publisher | dc.publisher | Academic Press | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Journal of Molecular and Cellular Cardiology | |
Keywords | dc.subject | Calcineurin | |
Keywords | dc.subject | Circadian rhythms | |
Keywords | dc.subject | Heart failure | |
Keywords | dc.subject | Microdomains | |
Keywords | dc.subject | Transmural gradient | |
Título | dc.title | Calcineurin signaling in the heart: The importance of time and place | |
Document type | dc.type | Artículo de revista | |
dcterms.accessRights | dcterms.accessRights | Acceso Abierto | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile