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Authordc.contributor.authorRocha, Gladys 
Authordc.contributor.authorSierralta, Walter 
Authordc.contributor.authorValladares Boasi, Luis 
Admission datedc.date.accessioned2019-03-18T11:55:34Z
Available datedc.date.available2019-03-18T11:55:34Z
Publication datedc.date.issued2016
Cita de ítemdc.identifier.citationRevista Medica de Chile, Volumen 144, Issue 11, 2018, Pages 1377-1381
Identifierdc.identifier.issn07176163
Identifierdc.identifier.issn00349887
Identifierdc.identifier.other10.4067/S0034-98872016001100002
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/167001
Abstractdc.description.abstract© 2016, Sociedad Medica de Santiago. All Rights Reserved. Background: The decline of estrogen levels increases cardiovascular risk in women. Platelets express estrogen receptors and 17β-estradiol- (E2) can produce a protective effect on thrombus formation. The hydroxylation of cholesterol generates several sterols and 27-hydroxycholesterol (27HC) predominates in circulation. Aim: To evaluate the effect of 27HC as an endogenous antagonist of the anti-aggregating properties of E2 in platelets of postmenopausal women. Material and Methods: Platelet function of postmenopausal women was evaluated ex-vivo. Platelets pre-incubated with 27HC in the presence or absence of E2, were stimulated with collagen. Aggregation was evaluated using turbidimetry using a Chrono-log aggregometer. Results: Collagen-stimulated platelet aggregation was significantly inhibited by E2. The inhibitory effect of E2 on collagen-stimulated platelet aggregation was significantly reversed in the presence of 27HC. Conclu
Lenguagedc.language.isoen
Publisherdc.publisherSociedad Medica de Santiago
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceRevista Medica de Chile
Keywordsdc.subject27-hydroxycholesterol
Keywordsdc.subjectEstradiol
Keywordsdc.subjectPlatelet Aggregation
Keywordsdc.subjectPostmenopause
Títulodc.title27- hydroxycholesterol reverses estradiol induced inhibition of platelet aggregation in postmenopausal women Efecto del 27- hidroxicolesterol en la acción antiplaquetaria de estradiol en mujeres postmenopáusicas
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile