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Author | dc.contributor.author | Apata, Mario | |
Author | dc.contributor.author | Arriaza, Bernado | |
Author | dc.contributor.author | Llop Romero, Elena | |
Author | dc.contributor.author | Moraga, Mauricio | |
Admission date | dc.date.accessioned | 2019-03-18T11:56:16Z | |
Available date | dc.date.available | 2019-03-18T11:56:16Z | |
Publication date | dc.date.issued | 2017 | |
Cita de ítem | dc.identifier.citation | American Journal of Physical Anthropology, Volumen 163, Issue 1, 2018, Pages 192-199 | |
Identifier | dc.identifier.issn | 10968644 | |
Identifier | dc.identifier.issn | 00029483 | |
Identifier | dc.identifier.other | 10.1002/ajpa.23193 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/167048 | |
Abstract | dc.description.abstract | © 2017 Wiley Periodicals, Inc. Objectives: Quebrada Camarones, in the Atacama Desert, has the highest arsenic levels in the Americas (>1,000 µg/L). However, the Camarones people have subsisted in this adverse environment during the last 7,000 years and have not presented any epidemiological emergencies. Therefore, to solve this conundrum we compared the frequencies of four protective genetic variants of the AS3MT gene associated with efficient arsenic metabolization, between the living populations of Camarones and two other populations historically exposed to lower levels of arsenic. Materials and Methods: The Chilean selected population samples come from Quebrada Camarones (n = 50) and the Azapa Valley (n = 47) in the north and San Juan de la Costa (n = 45) in southern Chile. The genotyping was conducted using PCR-RFLP. We compared the genotypic and allelic frequencies, and estimated the haplotype frequencies in the AS3MT gene. Results: We found higher frequencies of the protective va | |
Lenguage | dc.language.iso | en | |
Publisher | dc.publisher | Wiley-Liss Inc. | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | American Journal of Physical Anthropology | |
Keywords | dc.subject | AS3MT gene | |
Keywords | dc.subject | natural selection | |
Keywords | dc.subject | protective haplotype | |
Keywords | dc.subject | Quebrada Camarones | |
Título | dc.title | Human adaptation to arsenic in Andean populations of the Atacama Desert | |
Document type | dc.type | Artículo de revista | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile