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Author | dc.contributor.author | Pizarro Bauerle, Javier | |
Author | dc.contributor.author | Maldonado, Ismael | |
Author | dc.contributor.author | Sosoniuk Roche, Eduardo Rodrigo | |
Author | dc.contributor.author | Vallejos, Gerardo | |
Author | dc.contributor.author | López, Mercedes N. | |
Author | dc.contributor.author | Salazar Onfray, Flavio | |
Author | dc.contributor.author | Aguilar Guzmán, Lorena Andrea | |
Author | dc.contributor.author | Valck Calderón, Carolina Eliana | |
Author | dc.contributor.author | Ferreira, Arturo | |
Author | dc.contributor.author | Becker, María Inés | |
Admission date | dc.date.accessioned | 2019-03-18T11:56:16Z | |
Available date | dc.date.available | 2019-03-18T11:56:16Z | |
Publication date | dc.date.issued | 2017 | |
Cita de ítem | dc.identifier.citation | Frontiers in Immunology, Volumen 8, Issue FEB, 2018, | |
Identifier | dc.identifier.issn | 16643224 | |
Identifier | dc.identifier.other | 10.3389/fimmu.2017.00188 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/167051 | |
Abstract | dc.description.abstract | © 2017 Pizarro-Bauerle, Maldonado, Sosoniuk-Roche, Vallejos, López, Salazar-Onfray, Aguilar-Guzmán, Valck, Ferreira and Becker. Molluskan hemocyanins are enormous oxygen-carrier glycoproteins that show remarkable immunostimulatory properties when inoculated in mammals, such as the generation of high levels of antibodies, a strong cellular reaction, and generation of non-specific antitumor immune responses in some types of cancer, particularly for superficial bladder cancer. These proteins have the ability to bias the immune response toward a Th1 phenotype. However, despite all their current uses with beneficial clinical outcomes, a clear mechanism explaining these properties is not available. Taking into account reports of natural antibodies against the hemocyanin of the gastropod Megathura crenulata [keyhole limpet hemocyanin (KLH)] in humans as well as other vertebrate species, we report here for the first time, the presence, in sera from unimmunized healthy donors, of antibodies rec | |
Lenguage | dc.language.iso | en | |
Publisher | dc.publisher | Frontiers Research Foundation | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Frontiers in Immunology | |
Keywords | dc.subject | Adjuvants | |
Keywords | dc.subject | Carbohydrates | |
Keywords | dc.subject | Classical pathway | |
Keywords | dc.subject | Complement system | |
Keywords | dc.subject | Molluskan hemocyanins | |
Keywords | dc.subject | Natural antibodies | |
Título | dc.title | Molluskan hemocyanins activate the classical pathway of the human complement system through natural antibodies | |
Document type | dc.type | Artículo de revista | |
dcterms.accessRights | dcterms.accessRights | Acceso Abierto | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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