Mostrar el registro sencillo del ítem

Autordc.contributor.authorPereira-Montecinos, Camila 
Autordc.contributor.authorValiente-Echeverría, Fernando 
Autordc.contributor.authorSoto Rifo, Ricardo 
Fecha ingresodc.date.accessioned2019-03-18T11:56:17Z
Fecha disponibledc.date.available2019-03-18T11:56:17Z
Fecha de publicacióndc.date.issued2017
Cita de ítemdc.identifier.citationBiochimica et Biophysica Acta - Gene Regulatory Mechanisms, Volumen 1860, Issue 4, 2018, Pages 460-471
Identificadordc.identifier.issn18764320
Identificadordc.identifier.issn18749399
Identificadordc.identifier.other10.1016/j.bbagrm.2017.02.002
Identificadordc.identifier.urihttps://repositorio.uchile.cl/handle/2250/167060
Resumendc.description.abstract© 2017 RNA plays central roles in biology and novel functions and regulation mechanisms are constantly emerging. To accomplish some of their functions within the cell, RNA molecules undergo hundreds of chemical modifications from which N6-methyladenosine (m6A), inosine (I), pseudouridine (ψ) and 5-methylcytosine (5mC) have been described in eukaryotic mRNA. Interestingly, the m6A modification was shown to be reversible, adding novel layers of regulation of gene expression through what is now recognized as epitranscriptomics. The development of molecular mapping strategies coupled to next generation sequencing allowed the identification of thousand of modified transcripts in different tissues and under different physiological conditions such as viral infections. As intracellular parasites, viruses are confronted to cellular RNA modifying enzymes and, as a consequence, viral RNA can be chemically modified at some stages of the replication cycle. This review focuses on the chemical modifi
Idiomadc.language.isoen
Publicadordc.publisherElsevier B.V.
Tipo de licenciadc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link a Licenciadc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Fuentedc.sourceBiochimica et Biophysica Acta - Gene Regulatory Mechanisms
Palabras clavesdc.subjectEpitranscriptomics
Palabras clavesdc.subjectGene expression
Palabras clavesdc.subjectHCV
Palabras clavesdc.subjectHIV-1
Palabras clavesdc.subjectm6A
Palabras clavesdc.subjectViral replication
Palabras clavesdc.subjectZIKV
Títulodc.titleEpitranscriptomic regulation of viral replication
Tipo de documentodc.typeArtículo de revista
Catalogadoruchile.catalogadorSCOPUS
Indizaciónuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


Descargar archivo

Icon

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Attribution-NonCommercial-NoDerivs 3.0 Chile
Excepto si se señala otra cosa, la licencia del ítem se describe como Attribution-NonCommercial-NoDerivs 3.0 Chile