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Author | dc.contributor.author | Mamo, Tewodros | |
Author | dc.contributor.author | Mladek, Ann C. | |
Author | dc.contributor.author | Shogren, Kris L. | |
Author | dc.contributor.author | Gustafson, Carl | |
Author | dc.contributor.author | Gupta, Shiv K. | |
Author | dc.contributor.author | Riester, Scott M. | |
Author | dc.contributor.author | Maran, Avudaiappan | |
Author | dc.contributor.author | Galindo, Mario A. | |
Author | dc.contributor.author | van Wijnen, Andre J. | |
Author | dc.contributor.author | Sarkaria, Jann N. | |
Author | dc.contributor.author | Yaszemski, Michael J. | |
Admission date | dc.date.accessioned | 2019-03-18T11:56:19Z | |
Available date | dc.date.available | 2019-03-18T11:56:19Z | |
Publication date | dc.date.issued | 2017 | |
Cita de ítem | dc.identifier.citation | Biochemical and Biophysical Research Communications, Volumen 486, Issue 2, 2018, Pages 307-313 | |
Identifier | dc.identifier.issn | 10902104 | |
Identifier | dc.identifier.issn | 0006291X | |
Identifier | dc.identifier.other | 10.1016/j.bbrc.2017.03.033 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/167073 | |
Abstract | dc.description.abstract | © 2017 Elsevier Inc. Osteosarcoma survival rate has not improved over the past three decades, and the debilitating side effects of the surgical treatment suggest the need for alternative local control approaches. Radiotherapy is largely ineffective in osteosarcoma, indicating a potential role for radiosensitizers. Blocking DNA repair, particularly by inhibiting the catalytic subunit of DNA-dependent protein kinase (DNA-PKCS), is an attractive option for the radiosensitization of osteosarcoma. In this study, the expression of DNA-PKCS in osteosarcoma tissue specimens and cell lines was examined. Moreover, the small molecule DNA-PKCS inhibitor, KU60648, was investigated as a radiosensitizing strategy for osteosarcoma cells in vitro. DNA-PKCS was consistently expressed in the osteosarcoma tissue specimens and cell lines studied. Additionally, KU60648 effectively sensitized two of those osteosarcoma cell lines (143B cells by 1.5-fold and U2OS cells by 2.5-fold). KU60648 co-treatment also a | |
Lenguage | dc.language.iso | en | |
Publisher | dc.publisher | Elsevier B.V. | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Biochemical and Biophysical Research Communications | |
Keywords | dc.subject | DNA-PK | |
Keywords | dc.subject | DNA-PKcs | |
Keywords | dc.subject | KU60648 | |
Keywords | dc.subject | Osteosarcoma | |
Keywords | dc.subject | Radiosensitizers | |
Keywords | dc.subject | Radiotherapy | |
Título | dc.title | Inhibiting DNA-PKCS radiosensitizes human osteosarcoma cells | |
Document type | dc.type | Artículo de revista | |
dcterms.accessRights | dcterms.accessRights | Acceso Abierto | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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