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Author | dc.contributor.author | Farías, Jorge G. | |
Author | dc.contributor.author | Carrasco Pozo, Catalina | |
Author | dc.contributor.author | Carrasco Loza, Rodrigo | |
Author | dc.contributor.author | Sepúlveda, Néstor | |
Author | dc.contributor.author | Álvarez, Pedro | |
Author | dc.contributor.author | Quezada, Mauricio | |
Author | dc.contributor.author | Quiñones, John | |
Author | dc.contributor.author | Molina, Víctor | |
Author | dc.contributor.author | Castillo, Rodrigo L. | |
Admission date | dc.date.accessioned | 2019-03-18T11:59:27Z | |
Available date | dc.date.available | 2019-03-18T11:59:27Z | |
Publication date | dc.date.issued | 2017 | |
Cita de ítem | dc.identifier.citation | Experimental Biology and Medicine, Volumen 242, Issue 10, 2018, Pages 1104-1114 | |
Identifier | dc.identifier.issn | 15353699 | |
Identifier | dc.identifier.issn | 15353702 | |
Identifier | dc.identifier.other | 10.1177/1535370216649263 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/167148 | |
Abstract | dc.description.abstract | © 2016, © 2016 by the Society for Experimental Biology and Medicine. The mechanistic evidence to support the cardioprotective effects of polyunsaturated fatty acids (PUFA) are controversial. The aim was to test cardioprotective mechanisms induced by PUFA supplementation against cardiac ischemia-reperfusion (IR) injury. Ten-week-old male Wistar rats (225 ± 14 g, n = 14) were divided in two groups: rats without supplementation (n = 7) and a PUFA group, supplemented by PUFA (0.6 g/kg/day; DHA:EPA = 3:1) for eight weeks (n = 7). Hearts were perfused with Krebs–Henseleit buffer for 20 min (control conditions); others were subjected to control conditions, 30 min of global ischemia and 120 min of reperfusion (IR group). Infarct size (IS) and left ventricular developed pressure (LVDP) were measured at 120 min of reperfusion. Oxidative stress biomarkers (TBARS, total carbonyls), antioxidant status (CAT, catalase; SOD, superoxide dismutase; GSH-Px, glutathione peroxidase activity and GSH/GSSG ra | |
Lenguage | dc.language.iso | en | |
Publisher | dc.publisher | SAGE Publications Inc. | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Experimental Biology and Medicine | |
Keywords | dc.subject | infarct size | |
Keywords | dc.subject | NF-κB and Nrf2 | |
Keywords | dc.subject | oxidative stress | |
Keywords | dc.subject | Polyunsaturated fatty acids | |
Keywords | dc.subject | ventricular function | |
Título | dc.title | Polyunsaturated fatty acid induces cardioprotection against ischemia-reperfusion through the inhibition of NF-kappaB and induction of Nrf2 | |
Document type | dc.type | Artículo de revista | |
dcterms.accessRights | dcterms.accessRights | Acceso Abierto | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile