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Author | dc.contributor.author | Ruff, J. | |
Author | dc.contributor.author | Hüwel, S. | |
Author | dc.contributor.author | Kogan Bocian, Marcelo | |
Author | dc.contributor.author | Simon, Ulrich | |
Author | dc.contributor.author | Galla, Hans Joachim | |
Admission date | dc.date.accessioned | 2019-03-18T11:59:30Z | |
Available date | dc.date.available | 2019-03-18T11:59:30Z | |
Publication date | dc.date.issued | 2017 | |
Cita de ítem | dc.identifier.citation | Nanomedicine: Nanotechnology, Biology, and Medicine, Volumen 13, Issue 5, 2018, Pages 1645-1652 | |
Identifier | dc.identifier.issn | 15499642 | |
Identifier | dc.identifier.issn | 15499634 | |
Identifier | dc.identifier.other | 10.1016/j.nano.2017.02.013 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/167155 | |
Abstract | dc.description.abstract | © 2017 Elsevier Inc. We studied the effect of gold nanoparticle (AuNP) size, surface charge, concentration and morphology on the integrity of the blood–brain barrier (BBB) in a well-established in vitro model set-up. We focused on the effect of peptide functionalized hollow gold nanospheres and gold nanorods, which selectively bind to amyloidogenic β-amyloid structures. These AuNP conjugates have already been successfully tested as photothermal absorbers for potential application in Alzheimer's disease (AD) therapy in an in vitro set-up, but may exhibit a low passage through the BBB due to their overall negative charge. Our results show that: (i) small (1.4 nm) AuNPs strongly affects the BBB integrity, (ii) negative surface charge impedes BBB passage, and (iii) this charge effect caused by the peptide is compensated by covalent coupling to a polyethylene glycol ligand stabilizing the particles in diluted manner. | |
Lenguage | dc.language.iso | en | |
Publisher | dc.publisher | Elsevier Inc. | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Nanomedicine: Nanotechnology, Biology, and Medicine | |
Keywords | dc.subject | Blood–brain barrier | |
Keywords | dc.subject | Gold nanorods | |
Keywords | dc.subject | Hollow gold nanospheres | |
Keywords | dc.subject | Impedance spectroscopy | |
Título | dc.title | The effects of gold nanoparticles functionalized with ß-amyloid specific peptides on an in vitro model of blood–brain barrier | |
Document type | dc.type | Artículo de revista | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile