Synaptic configuration of quadrivalents and their association with the XY bivalent in spermatocytes of Robertsonian heterozygotes of Mus domesticus
Author
dc.contributor.author
Berríos, Soledad
Author
dc.contributor.author
Fernández Donoso, Raúl
Author
dc.contributor.author
Ayarza, Eliana
Admission date
dc.date.accessioned
2019-03-18T12:01:28Z
Available date
dc.date.available
2019-03-18T12:01:28Z
Publication date
dc.date.issued
2017
Cita de ítem
dc.identifier.citation
Biological research, Volumen 50, Issue 1, 2018,
Identifier
dc.identifier.issn
07176287
Identifier
dc.identifier.other
10.1186/s40659-017-0143-6
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/167412
Abstract
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BACKGROUND: The nuclear architecture of meiotic prophase spermatocytes is based on higher-order patterns of spatial associations among chromosomal domains and consequently is prone to modification by chromosomal rearrangements. We have shown that nuclear architecture is modified in spermatocytes of Robertsonian (Rb) homozygotes of Mus domesticus. In this study we analyse the synaptic configuration of the quadrivalents formed in the meiotic prophase of spermatocytes of mice double heterozygotes for the dependent Rb chromosomes: Rbs 11.16 and 16.17. RESULTS: Electron microscope spreads of 60 pachytene spermatocytes from four animals of Mus domesticus 2n = 38 were studied and their respective quadrivalents analysed in detail. Normal synaptonemal complex was found between arms 16 of the Rb metacentric chromosomes, telocentrics 11 and 17 and homologous arms of the Rb metacentric chromosomes. About 43% of the quadrivalents formed a synaptonemal complex between the heterologous short arms of