Show simple item record
Author | dc.contributor.author | Lebeaupin, Cynthia | |
Author | dc.contributor.author | Vallée, Deborah | |
Author | dc.contributor.author | Hazari, Younis | |
Author | dc.contributor.author | Hetz Flores, Claudio | |
Author | dc.contributor.author | Chevet, Eric | |
Author | dc.contributor.author | Bailly-Maitre, Béatrice | |
Admission date | dc.date.accessioned | 2019-03-18T12:03:16Z | |
Available date | dc.date.available | 2019-03-18T12:03:16Z | |
Publication date | dc.date.issued | 2018 | |
Cita de ítem | dc.identifier.citation | Journal of Hepatology, Volumen 69, Issue 4, 2018, Pages 927-947 | |
Identifier | dc.identifier.issn | 16000641 | |
Identifier | dc.identifier.issn | 01688278 | |
Identifier | dc.identifier.other | 10.1016/j.jhep.2018.06.008 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/167576 | |
Abstract | dc.description.abstract | © 2018 The global epidemic of obesity has been accompanied by a rising burden of non-alcoholic fatty liver disease (NAFLD), with manifestations ranging from simple steatosis to non-alcoholic steatohepatitis, potentially developing into hepatocellular carcinoma. Although much attention has focused on NAFLD, its pathogenesis remains largely obscure. The hallmark of NAFLD is the hepatic accumulation of lipids, which subsequently leads to cellular stress and hepatic injury, eventually resulting in chronic liver disease. Abnormal lipid accumulation often coincides with insulin resistance in steatotic livers and is associated with perturbed endoplasmic reticulum (ER) proteostasis in hepatocytes. In response to chronic ER stress, an adaptive signalling pathway known as the unfolded protein response is triggered to restore ER proteostasis. However, the unfolded protein response can cause inflammation, inflammasome activation and, in the case of non-resolvable ER stress, the death of hepatocyte | |
Lenguage | dc.language.iso | en | |
Publisher | dc.publisher | Elsevier B.V. | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Journal of Hepatology | |
Keywords | dc.subject | Cell death | |
Keywords | dc.subject | Endoplasmic Reticulum Stress | |
Keywords | dc.subject | Inflammation | |
Keywords | dc.subject | Liver Cancer | |
Keywords | dc.subject | Steatohepatitis | |
Keywords | dc.subject | Steatosis | |
Keywords | dc.subject | Therapeutic Targets | |
Keywords | dc.subject | Unfolded Protein Response | |
Título | dc.title | Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease | |
Document type | dc.type | Artículo de revista | |
dcterms.accessRights | dcterms.accessRights | Acceso Abierto | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
Files in this item
- Name:
- Lebeaupin%20et%20al_Endoplasmi ...
- Size:
- 1.209Mb
- Format:
- PDF
This item appears in the following Collection(s)
Show simple item record
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile