Show simple item record
Author | dc.contributor.author | Ponnappa, Biddanda C. | |
Author | dc.contributor.author | Israel Jacard, Yedy | |
Admission date | dc.date.accessioned | 2019-03-18T12:03:18Z | |
Available date | dc.date.available | 2019-03-18T12:03:18Z | |
Publication date | dc.date.issued | 2002 | |
Cita de ítem | dc.identifier.citation | Frontiers in Bioscience - Landmark, Volumen 7, Issue 5, 2018, Pages 223-233 | |
Identifier | dc.identifier.issn | 10934715 | |
Identifier | dc.identifier.issn | 10939946 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/167592 | |
Abstract | dc.description.abstract | © 2002 Frontiers in Bioscience. All rights reserved.During proinflammatory reactions such as endotoxemia, ischemia-reperfusion and immune reactions, excessive amounts of cytokines and prostanoids are released resulting in liver injury. In the liver, Kupffer cells are the primary source of cytokines and prostanoids. Obliteration of Kupffer cells prevents experimentally-induced liver damage, suggesting a major role for Kupffer in the pathogenesis of liver diseases. Pretreatment of experimental animals with antibodies directed against cytokines such as tumor necrosis alpha (TNF-alpha) prevented experimentally-induced liver damage. In recent years, antisense oligonucleotides (ASOs) directed against specific mRNAs have been tested as an alternative therapy to control the excessive production of inflammatory peptides. Although ASOs have great potential against gene expression, their design, in vivo delivery and stability, have posed significant challenges. Computer-aided configurational anal | |
Lenguage | dc.language.iso | en | |
Publisher | dc.publisher | Frontiers in Bioscience | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Frontiers in Bioscience - Landmark | |
Keywords | dc.subject | Antisense | |
Keywords | dc.subject | Cytokine | |
Keywords | dc.subject | Delivery | |
Keywords | dc.subject | Inflammation | |
Keywords | dc.subject | Kupffer Cell | |
Keywords | dc.subject | Liposome | |
Keywords | dc.subject | Liver | |
Keywords | dc.subject | Oligonucleotide | |
Keywords | dc.subject | PH-sensitive | |
Keywords | dc.subject | Review | |
Keywords | dc.subject | TNF-alpha | |
Título | dc.title | Targeting kupffer cells with antisense oligonucleotides | |
Document type | dc.type | Artículo de revista | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
Files in this item
- Name:
- item_85052012370.pdf
- Size:
- 1.980Kb
- Format:
- PDF
This item appears in the following Collection(s)
Show simple item record
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile