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Authordc.contributor.authorPonnappa, Biddanda C. 
Authordc.contributor.authorIsrael Jacard, Yedy 
Admission datedc.date.accessioned2019-03-18T12:03:18Z
Available datedc.date.available2019-03-18T12:03:18Z
Publication datedc.date.issued2002
Cita de ítemdc.identifier.citationFrontiers in Bioscience - Landmark, Volumen 7, Issue 5, 2018, Pages 223-233
Identifierdc.identifier.issn10934715
Identifierdc.identifier.issn10939946
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/167592
Abstractdc.description.abstract© 2002 Frontiers in Bioscience. All rights reserved.During proinflammatory reactions such as endotoxemia, ischemia-reperfusion and immune reactions, excessive amounts of cytokines and prostanoids are released resulting in liver injury. In the liver, Kupffer cells are the primary source of cytokines and prostanoids. Obliteration of Kupffer cells prevents experimentally-induced liver damage, suggesting a major role for Kupffer in the pathogenesis of liver diseases. Pretreatment of experimental animals with antibodies directed against cytokines such as tumor necrosis alpha (TNF-alpha) prevented experimentally-induced liver damage. In recent years, antisense oligonucleotides (ASOs) directed against specific mRNAs have been tested as an alternative therapy to control the excessive production of inflammatory peptides. Although ASOs have great potential against gene expression, their design, in vivo delivery and stability, have posed significant challenges. Computer-aided configurational anal
Lenguagedc.language.isoen
Publisherdc.publisherFrontiers in Bioscience
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceFrontiers in Bioscience - Landmark
Keywordsdc.subjectAntisense
Keywordsdc.subjectCytokine
Keywordsdc.subjectDelivery
Keywordsdc.subjectInflammation
Keywordsdc.subjectKupffer Cell
Keywordsdc.subjectLiposome
Keywordsdc.subjectLiver
Keywordsdc.subjectOligonucleotide
Keywordsdc.subjectPH-sensitive
Keywordsdc.subjectReview
Keywordsdc.subjectTNF-alpha
Títulodc.titleTargeting kupffer cells with antisense oligonucleotides
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile