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Authordc.contributor.authorBarrera, Cynthia 
Authordc.contributor.authorValenzuela, Rodrigo 
Authordc.contributor.authorRincón, Miguel Ángel 
Authordc.contributor.authorEspinosa, Alejandra 
Authordc.contributor.authorEcheverria, Francisca 
Authordc.contributor.authorRomero, Nalda 
Authordc.contributor.authorGonzalez-Mañan, Daniel 
Authordc.contributor.authorVidela Cabrera, Luis 
Admission datedc.date.accessioned2019-03-18T12:03:25Z
Available datedc.date.available2019-03-18T12:03:25Z
Publication datedc.date.issued2018
Cita de ítemdc.identifier.citationFree Radical Biology and Medicine, Volumen 126,
Identifierdc.identifier.issn18734596
Identifierdc.identifier.issn08915849
Identifierdc.identifier.other10.1016/j.freeradbiomed.2018.08.030
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/167622
Abstractdc.description.abstract© 2018 Elsevier Inc. Enhanced iron levels in liver are associated with oxidative stress development and damage with increased fat accumulation. The aim of this work was to assess the hypothesis that antioxidant-rich extra virgin olive oil (AR-EVOO) counteracts iron-rich diet (IRD)-induced oxidative stress hindering hepatic steatosis. Male Wistar rats were fed and IRD (200 mg iron/kg diet) versus a control diet (CD; 50 mg iron/kg diet) with alternate AR-EVOO supplementation (100 mg/day) for 21 days. IRD induced liver steatosis and oxidative stress (higher levels of protein oxidation and lipid peroxidation with glutathione depletion), mitochondrial dysfunction (decreased citrate synthase and complex I and II activities) and loss of polyunsaturated fatty acids (PUFAs), with a drastic enhancement in the sterol regulatory element-binding protein-1c (SREBP-1c)/peroxisome proliferator-activated receptor-α (PPAR-α) ratio upregulating the expression of lipogenic enzymes (acetyl-CoA carboxylase,
Lenguagedc.language.isoen
Publisherdc.publisherElsevier Inc.
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceFree Radical Biology and Medicine
Keywordsdc.subjectAntioxidant-rich extra virgin olive oil
Keywordsdc.subjectIron
Keywordsdc.subjectLCPUFA depletion
Keywordsdc.subjectLiver steatosis
Keywordsdc.subjectOxidative stress
Títulodc.titleMolecular mechanisms related to the hepatoprotective effects of antioxidant-rich extra virgin olive oil supplementation in rats subjected to short-term iron administration
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile