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Author | dc.contributor.author | González Hormazábal, Patricio | |
Author | dc.contributor.author | Romero, Sandra | |
Author | dc.contributor.author | Musleh, Maher | |
Author | dc.contributor.author | Bustamante, Marco | |
Author | dc.contributor.author | Stambuk, Juan | |
Author | dc.contributor.author | Pisano, Raul | |
Author | dc.contributor.author | Lanzarini, Enrique | |
Author | dc.contributor.author | Chiong, Hector | |
Author | dc.contributor.author | Rojas, Jorge | |
Author | dc.contributor.author | Castro, Victor Gonzalo | |
Author | dc.contributor.author | Jara, Lilian | |
Author | dc.contributor.author | Berger, Zoltan | |
Admission date | dc.date.accessioned | 2019-03-18T12:03:45Z | |
Available date | dc.date.available | 2019-03-18T12:03:45Z | |
Publication date | dc.date.issued | 2018 | |
Cita de ítem | dc.identifier.citation | Anticancer Research, Volumen 38, Issue 10, 2018, Pages 5703-5708 | |
Identifier | dc.identifier.issn | 17917530 | |
Identifier | dc.identifier.issn | 02507005 | |
Identifier | dc.identifier.other | 10.21873/anticanres.12907 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/167652 | |
Abstract | dc.description.abstract | © 2018 International Institute of Anticancer Research. All rights reserved. Background/Aim: Inflammation is a key process in gastric carcinogenesis. Cytokines are mediators of inflammation and are involved in metastasis and tumorigenicity. We previously assessed the role of cytokine gene polymorphisms in gastric cancer risk in Chile. In the present study, we aimed to analyze whether these polymorphisms are associated with overall survival (OS) in gastric cancer (GC) patients. Patients and Methods: A total of 153 individuals with GC diagnosis were followed-up for at least 2 years. Hazard ratios (HR) were estimated from Cox regression models using SNPs as predictor variables. The following SNPs were genotyped for study using a TaqMan assay: rs16944 (IL1B -511C>T); rs4073 (IL8 -251 T>A); rs2275913 (IL-17 -197G>A); rs1800872 (IL10 -592 C>A); rs1800896 (IL10 -1082A>G); rs28372698 (IL32). Results: Interleukin-8 rs4073 (IL-8 -251T>A) showed association with OS under the dominant model (TA + A | |
Lenguage | dc.language.iso | en | |
Publisher | dc.publisher | International Institute of Anticancer Research | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Anticancer Research | |
Keywords | dc.subject | Gastric cancer | |
Keywords | dc.subject | Interleukin-8 | |
Keywords | dc.subject | Polymorphisms | |
Keywords | dc.subject | Prognosis | |
Keywords | dc.subject | SNP | |
Keywords | dc.subject | Survival | |
Título | dc.title | IL-8-251T>A (rs4073) polymorphism is associated with prognosis in gastric cancer patients | |
Document type | dc.type | Artículo de revista | |
dcterms.accessRights | dcterms.accessRights | Acceso Abierto | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile