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Author | dc.contributor.author | Binder, Alexandra M. | |
Author | dc.contributor.author | Stiemsma, Leah T. | |
Author | dc.contributor.author | Keller, Kristen | |
Author | dc.contributor.author | Van Otterdijk, Sanne D. | |
Author | dc.contributor.author | Mericq, Verónica | |
Author | dc.contributor.author | Pereira, Ana | |
Author | dc.contributor.author | Santos, José Luis | |
Author | dc.contributor.author | Shepherd, John | |
Author | dc.contributor.author | Michels, Karin B. | |
Admission date | dc.date.accessioned | 2019-03-18T12:03:46Z | |
Available date | dc.date.available | 2019-03-18T12:03:46Z | |
Publication date | dc.date.issued | 2018 | |
Cita de ítem | dc.identifier.citation | Clinical Epigenetics, Volumen 10, Issue 1, 2018, | |
Identifier | dc.identifier.issn | 18687083 | |
Identifier | dc.identifier.issn | 18687075 | |
Identifier | dc.identifier.other | 10.1186/s13148-018-0553-5 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/167665 | |
Abstract | dc.description.abstract | © 2018 The Author(s). Background: Estrogen receptor-α (ER-α) is a transcriptional regulator, which mediates estrogen-dependent breast development, as well as breast tumorigenesis. The influence of epigenetic regulation of ER-α on adolescent breast composition has not been previously studied and could serve as a marker of pubertal health and susceptibility to breast cancer. We investigated the association between ER-α DNA methylation in leukocytes and breast composition in adolescent Chilean girls enrolled in the Growth and Obesity Cohort Study (GOCS) in Santiago, Chile. Breast composition (total breast volume (BV; cm3), fibroglandular volume (FGV; cm3), and percent fibroglandular volume (%FGV)) was measured at breast Tanner stage 4 (B4). ER-α promoter DNA methylation was assessed by pyrosequencing in blood samples collected at breast Tanner stages 2 (B2; n = 256) and B4 (n = 338). Results: After adjusting for fat percentage at breast density measurement, ER-α methylation at B2, and cel | |
Lenguage | dc.language.iso | en | |
Publisher | dc.publisher | BioMed Central Ltd. | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Clinical Epigenetics | |
Keywords | dc.subject | Breast density | |
Keywords | dc.subject | DNA methylation | |
Keywords | dc.subject | Epigenetics | |
Keywords | dc.subject | Estrogen receptor-α | |
Keywords | dc.subject | Fibroglandular volume | |
Título | dc.title | Inverse association between estrogen receptor-α DNA methylation and breast composition in adolescent Chilean girls | |
Document type | dc.type | Artículo de revista | |
dcterms.accessRights | dcterms.accessRights | Acceso Abierto | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile