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Autordc.contributor.authorBenites, Julio 
Autordc.contributor.authorToledo, Héctor 
Autordc.contributor.authorSalas, Felipe 
Autordc.contributor.authorGuerrero, Angélica 
Autordc.contributor.authorRios, David 
Autordc.contributor.authorValderrama, Jaime A. 
Autordc.contributor.authorCalderon, Pedro Buc 
Fecha ingresodc.date.accessioned2019-03-18T12:03:49Z
Fecha disponibledc.date.available2019-03-18T12:03:49Z
Fecha de publicacióndc.date.issued2018
Cita de ítemdc.identifier.citationOxidative medicine and cellular longevity, Volumen 2018,
Identificadordc.identifier.issn19420994
Identificadordc.identifier.other10.1155/2018/1618051
Identificadordc.identifier.urihttps://repositorio.uchile.cl/handle/2250/167676
Resumendc.description.abstractInfection by Helicobacter pylori increases 10 times the risk of developing gastric cancer. Juglone, a natural occurring 1,4-naphthoquinone, prevents H. pylori growth by interfering with some of its critical metabolic pathways. Here, we report the design, synthesis, and in vitro evaluation of a series of juglone derivatives, namely, 2/3-phenylaminojuglones, as potential H. pylori growth inhibitors. Results show that 5 out of 12 phenylaminojuglones (at 1.5 μg/mL) were 1.5-2.2-fold more active than juglone. Interestingly, most of the phenylaminojuglones (10 out of 12) were 1.1-2.8 fold more active than metronidazole, a known H. pylori growth inhibitor. The most active compound, namely, 2-((3,4,5-trimethoxyphenyl)amino)-5-hydroxynaphthalene-1,4-dione 7, showed significant higher halo of growth inhibitions (HGI = 32.25 mm) to that of juglone and metronidazole (HGI = 14.50 and 11.67 mm). Structural activity relationships of the series suggest that the nature and location of the nitrogen subs
Idiomadc.language.isoen
Tipo de licenciadc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link a Licenciadc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Fuentedc.sourceOxidative medicine and cellular longevity
Palabras clavesdc.subjectBiochemistry
Palabras clavesdc.subjectAging
Palabras clavesdc.subjectCell Biology
Títulodc.titleIn Vitro Inhibition of Helicobacter pylori Growth by Redox Cycling Phenylaminojuglones
Tipo de documentodc.typeArtículo de revista
dcterms.accessRightsdcterms.accessRightsAcceso Abierto
Catalogadoruchile.catalogadorSCOPUS
Indizaciónuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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