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In Vitro Inhibition of Helicobacter pylori Growth by Redox Cycling Phenylaminojuglones
Autor | dc.contributor.author | Benites, Julio | |
Autor | dc.contributor.author | Toledo, Héctor | |
Autor | dc.contributor.author | Salas, Felipe | |
Autor | dc.contributor.author | Guerrero, Angélica | |
Autor | dc.contributor.author | Rios, David | |
Autor | dc.contributor.author | Valderrama, Jaime A. | |
Autor | dc.contributor.author | Calderon, Pedro Buc | |
Fecha ingreso | dc.date.accessioned | 2019-03-18T12:03:49Z | |
Fecha disponible | dc.date.available | 2019-03-18T12:03:49Z | |
Fecha de publicación | dc.date.issued | 2018 | |
Cita de ítem | dc.identifier.citation | Oxidative medicine and cellular longevity, Volumen 2018, | |
Identificador | dc.identifier.issn | 19420994 | |
Identificador | dc.identifier.other | 10.1155/2018/1618051 | |
Identificador | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/167676 | |
Resumen | dc.description.abstract | Infection by Helicobacter pylori increases 10 times the risk of developing gastric cancer. Juglone, a natural occurring 1,4-naphthoquinone, prevents H. pylori growth by interfering with some of its critical metabolic pathways. Here, we report the design, synthesis, and in vitro evaluation of a series of juglone derivatives, namely, 2/3-phenylaminojuglones, as potential H. pylori growth inhibitors. Results show that 5 out of 12 phenylaminojuglones (at 1.5 μg/mL) were 1.5-2.2-fold more active than juglone. Interestingly, most of the phenylaminojuglones (10 out of 12) were 1.1-2.8 fold more active than metronidazole, a known H. pylori growth inhibitor. The most active compound, namely, 2-((3,4,5-trimethoxyphenyl)amino)-5-hydroxynaphthalene-1,4-dione 7, showed significant higher halo of growth inhibitions (HGI = 32.25 mm) to that of juglone and metronidazole (HGI = 14.50 and 11.67 mm). Structural activity relationships of the series suggest that the nature and location of the nitrogen subs | |
Idioma | dc.language.iso | en | |
Tipo de licencia | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link a Licencia | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Fuente | dc.source | Oxidative medicine and cellular longevity | |
Palabras claves | dc.subject | Biochemistry | |
Palabras claves | dc.subject | Aging | |
Palabras claves | dc.subject | Cell Biology | |
Título | dc.title | In Vitro Inhibition of Helicobacter pylori Growth by Redox Cycling Phenylaminojuglones | |
Tipo de documento | dc.type | Artículo de revista | |
dcterms.accessRights | dcterms.accessRights | Acceso Abierto | |
Catalogador | uchile.catalogador | SCOPUS | |
Indización | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI |
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