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Authordc.contributor.authorGarcía González, Paulina 
Authordc.contributor.authorCabral Miranda, Felipe 
Authordc.contributor.authorHetz Flores, Claudio
Authordc.contributor.authorOsorio Olivares, Fabiola 
Admission datedc.date.accessioned2019-03-18T12:03:55Z
Available datedc.date.available2019-03-18T12:03:55Z
Publication datedc.date.issued2018
Cita de ítemdc.identifier.citationFrontiers in Immunology, Volumen 9, Issue NOV, 2018,
Identifierdc.identifier.issn16643224
Identifierdc.identifier.other10.3389/fimmu.2018.02541
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/167713
Abstractdc.description.abstractCopyright © 2018 García-González, Cabral-Miranda, Hetz and Osorio. Emerging evidence suggests that the immune and nervous systems are in close interaction in health and disease conditions. Protein aggregation and proteostasis dysfunction at the level of the endoplasmic reticulum (ER) are central contributors to neurodegenerative diseases. The unfolded protein response (UPR) is the main transduction pathway that maintains protein homeostasis under conditions of protein misfolding and aggregation. Brain inflammation often coexists with the degenerative process in different brain diseases. Interestingly, besides its well-described role in neuronal fitness, the UPR has also emerged as a key regulator of ontogeny and function of several immune cell types. Nevertheless, the contribution of the UPR to brain inflammation initiated by immune cells remains largely unexplored. In this review, we provide a perspective on the potential role of ER stress signaling in brain-associated immune cells an
Lenguagedc.language.isoen
Publisherdc.publisherFrontiers Media S.A.
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceFrontiers in Immunology
Keywordsdc.subjectER stress
Keywordsdc.subjectImmune cells
Keywordsdc.subjectImmune system
Keywordsdc.subjectInflammation
Keywordsdc.subjectMisfolded proteins
Keywordsdc.subjectNeurodegeneration
Keywordsdc.subjectProtein protein misfolding diseases
Keywordsdc.subjectUPR
Títulodc.titleFunction in the development of neurodegenerative diseases
Document typedc.typeArtículo de revista
dcterms.accessRightsdcterms.accessRightsAcceso Abierto
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile