Show simple item record

Authordc.contributor.authorÁlvarez, Daniela 
Authordc.contributor.authorCeballo, Karina 
Authordc.contributor.authorOlguín, Sofía 
Authordc.contributor.authorMartínez Pinto, Jonathan Eloy 
Authordc.contributor.authorMaliqueo Yevilao, Manuel 
Authordc.contributor.authorFernandois, Daniela 
Authordc.contributor.authorSotomayor Zárate, Ramón 
Authordc.contributor.authorCruz, Gonzalo 
Cita de ítemdc.identifier.citationThe Journal of endocrinology, Volumen 239, Issue 3, 2018, Pages 325-338
Abstractdc.description.abstractMaternal obesity causes a wide range of impairment in offspring, such as metabolic and reproductive dysfunctions. We previously demonstrated that female offspring of obese rats have increased serum estradiol levels during early postnatal life, probably because of decreased hepatic cytochrome P450 3A2 levels, which could lead to early onset of puberty and polycystic ovary condition in adulthood. Using metformin during pregnancy and nursing to improve the metabolic status of obese mothers could prevent the sequence of events that lead to an increase in postnatal serum estradiol levels in female offspring and, hence, reproductive dysfunction. We found that metformin prevented an increase in serum estradiol levels at postnatal day 14 in female offspring of obese mothers, which was associated with a restoration of hepatic cytochrome P450 3A2 levels to control values. Treatment using metformin could not prevent advanced puberty, but we observed that the number of antral follicles, follicular
Publisherdc.publisherBioScientifica Ltd.
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceThe Journal of endocrinology
Keywordsdc.subjectmaternal obesity
Keywordsdc.subjectovarian function
Keywordsdc.subjectsympathetic activity
Títulodc.titlePrenatal metformin treatment improves ovarian function in offspring of obese rats
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile