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Authordc.contributor.authorHerbort, Carl P. 
Authordc.contributor.authorAbu El Asrar, Ahmed M. 
Authordc.contributor.authorTakeuchi, Masuru 
Authordc.contributor.authorPavésio, Carlos E. 
Authordc.contributor.authorCouto, Cristobal 
Authordc.contributor.authorHedayatfar, Alireza 
Authordc.contributor.authorMaruyama, Kazuichi 
Authordc.contributor.authorRao, Xi 
Authordc.contributor.authorSilpa-archa, Sukhum 
Authordc.contributor.authorSomkijrungroj, Thanapong 
Admission datedc.date.accessioned2019-10-11T17:27:21Z
Available datedc.date.available2019-10-11T17:27:21Z
Publication datedc.date.issued2019
Cita de ítemdc.identifier.citationInternational Ophthalmology, Volumen 39, Issue 6, 2019, Pages 1419-1425
Identifierdc.identifier.issn15732630
Identifierdc.identifier.issn01655701
Identifierdc.identifier.other10.1007/s10792-018-0949-4
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/171176
Abstractdc.description.abstract© 2018, The Author(s).Purpose: Vogt–Koyanagi–Harada (VKH) disease is a primary autoimmune granulomatous choroiditis that begins in the choroidal stroma. The aim of this review was to gather a body of evidence for the concept of a window of therapeutic opportunity, defined as a time interval following initial-onset disease during which adequate treatment will substantially modify the disease outcome and possibly even lead to cure, similar to what has been described for rheumatoid arthritis. Methods: We reviewed the literature and consulted leading experts in VKH disease to determine the consensus for the notion of a therapeutic window of opportunity in VKH disease. Results: We found a substantial body of evidence in the literature that a therapeutic window of opportunity exists for initial-onset acute uveitis associated with VKH disease. The disease outcome can be substantially improved if dual systemic steroidal and non-steroidal immunosuppressants are given within 2–3 weeks of the ons
Lenguagedc.language.isoen
Publisherdc.publisherSpringer Netherlands
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceInternational Ophthalmology
Keywordsdc.subjectAutoimmune disease
Keywordsdc.subjectImmunosuppressive therapy
Keywordsdc.subjectIndocyanine green angiography
Keywordsdc.subjectSunset glow fundus
Keywordsdc.subjectTherapeutic window of opportunity stromal choroiditis
Keywordsdc.subjectVogt–Koyanagi–Harada disease
Títulodc.titleCatching the therapeutic window of opportunity in early initial-onset Vogt–Koyanagi–Harada uveitis can cure the disease
Document typedc.typeArtículo de revista
dcterms.accessRightsdcterms.accessRightsAcceso Abierto
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile