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Author dc.contributor.author Videla Cabrera, Luis
Admission date dc.date.accessioned 2019-10-30T15:28:55Z
Available date dc.date.available 2019-10-30T15:28:55Z
Publication date dc.date.issued 2019
Cita de ítem dc.identifier.citation IUBMB Life, Volumen 71, Issue 9, 2019, Pages 1211-1220
Identifier dc.identifier.issn 15216551
Identifier dc.identifier.issn 15216543
Identifier dc.identifier.other 10.1002/iub.2067
Identifier dc.identifier.uri https://repositorio.uchile.cl/handle/2250/172410
Abstract dc.description.abstract Liver preconditioning (PC) refers to the development of an enhanced tolerance to injuring stimuli. For example, the protection from ischemia–reperfusion (IR) in the liver that is obtained by previous maneuvers triggering beneficial molecular and functional changes. Recently, we have assessed the PC effects of thyroid hormone (T3; single dose of 0.1 mg/kg) and n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs; daily doses of 450 mg/kg for 7 days) that abrogate IR injury to the liver. This feature is also achieved by a combined T3 and the n-3 LCPUFA docosahexaenoic acid (DHA) using a reduced period of supplementation of the FA (daily doses of 300 mg/kg for 3 days) and half of the T3 dosage (0.05 mg/kg). T3-dependent protective mechanisms include (i) the reactive oxygen species (ROS)-dependent activation of transcription factors nuclear factor-κB (NF-κB), AP-1, signal transducer and activator of transcription 3, and nuclear factor erythroid-2-related factor 2 (Nrf2) upregulating the expression of protective proteins. (ii) ROS-induced endoplasmic reticulum stress affording proper protein folding. (iii) The autophagy response to produce FAs for oxidation and ATP supply and amino acids for protein synthesis. (iv) Downregulation of inflammasome nucleotide-bonding oligomerization domain leucine-rich repeat containing family pyrin containing 3 and interleukin-1β expression to prevent inflammation. N-3 LCPUFAs induce antioxidant responses due to Nrf2 upregulation, with inflammation resolution being related to production of oxidation products and NF-κB downregulation. Energy supply to achieve liver PC is met by the combined DHA plus T3 protocol through upregulation of AMPK coupled to peroxisome proliferator-activated receptor-γ coactivator 1α signaling. In conclusion, DHA plus T3 coadministration favors hepatic bioenergetics and lipid homeostasis that is of crucial importance in acute and clinical conditions such as IR, which may be extended to long-term or chronic situations including steatosis in obesity and diabetes. © 2019 IUBMB Life, 71(9):1211–1220, 2019.
Lenguage dc.language.iso en
Publisher dc.publisher Blackwell Publishing Ltd
Type of license dc.rights Attribution-NonCommercial-NoDerivs 3.0 Chile
Link to License dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Source dc.source IUBMB Life
Keywords dc.subject AMP-activated protein kinase
Keywords dc.subject docosahexaenoic acid
Keywords dc.subject ischemia–reperfusion inflammatory injury
Keywords dc.subject liver preconditioning
Keywords dc.subject n-3 long-chain polyunsaturated fatty acids
Keywords dc.subject peroxisome proliferator-activated receptor γ coactivator-1α
Keywords dc.subject thyroid hormone (T3)
Título dc.title Combined docosahexaenoic acid and thyroid hormone supplementation as a protocol supporting energy supply to precondition and afford protection against metabolic stress situations
Document type dc.type Artículo de revista
Cataloguer uchile.catalogador SCOPUS
Indexation uchile.index Artículo de publicación SCOPUS
uchile.cosecha uchile.cosecha SI
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