Emerging roles of the endoplasmic reticulum associated unfolded protein response in cancer cell migration and invasion
Author
dc.contributor.author
Limia, Celia Maria
Author
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Sauzay, Chloé
Author
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Urra, Hery
Author
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Hetz Flores, Claudio
Author
dc.contributor.author
Chevet, Eric
Author
dc.contributor.author
Avril, Tony
Admission date
dc.date.accessioned
2019-10-30T15:28:56Z
Available date
dc.date.available
2019-10-30T15:28:56Z
Publication date
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2019
Cita de ítem
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Cancers, Volumen 11, Issue 5, 2019,
Identifier
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20726694
Identifier
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10.3390/cancers11050631
Identifier
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https://repositorio.uchile.cl/handle/2250/172417
Abstract
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Endoplasmic reticulum (ER) proteostasis is often altered in tumor cells due to intrinsic (oncogene expression, aneuploidy) and extrinsic (environmental) challenges. ER stress triggers the activation of an adaptive response named the Unfolded Protein Response (UPR), leading to protein translation repression, and to the improvement of ER protein folding and clearance capacity. The UPR is emerging as a key player in malignant transformation and tumor growth, impacting on most hallmarks of cancer. As such, the UPR can influence cancer cells’ migration and invasion properties. In this review, we overview the involvement of the UPR in cancer progression. We discuss its cross-talks with the cell migration and invasion machinery. Specific aspects will be covered including extracellular matrix (ECM) remodeling, modification of cell adhesion, chemo-attraction, epithelial-mesenchymal transition (EMT), modulation of signaling pathways associated with cell mobility, and cytoskeleton remodeling. The therapeutic potential of targeting the UPR to treat cancer will also be considered with specific emphasis in the impact on metastasis and tissue invasion.